Is pseudomembranous colitis a side effect of clindamycin?
All antibiotics, except parenteral aminoglycosides, sulfonamides and vancomycin, can induce pseudomembranous colitis. The worst offenders are clindamycin, ampicillin, amoxicillin and the cephalosporins. The cytotoxin produced by Clostridium difficile has been identified as the cause of pseudomembranous colitis.
Why does clindamycin cause colitis?
Using antibiotics can cause the bacterium Clostridium difficile (C. diff) to grow and infect the lining of the intestine, which produces the inflammation. Certain antibiotics, like penicillin, clindamycin (Cleocin®), the cephalosporins and the fluoroquinolones, make C. diff overgrowth more likely.
Can clindamycin cause C diff?
Although most antibiotics can increase the risk of developing C. difficile colitis, clindamycin, fluoroquinolones, or cephalosporins are most highly associated with subsequent development of C. difficile infection (2).
How common is colitis from clindamycin?
The frequent association of PMC with clindamycin in the 1970s caused the condition to become known as “clindamycin colitis.”21 The incidence of C. difficile–induced colitis as a complication of clindamycin therapy has been reported to range from 2% to 10%.
How long does diarrhea last after clindamycin?
About 1 in 5 people who take antibiotics develop antibiotic-associated diarrhea. Most often, antibiotic-associated diarrhea is mild and requires no treatment. The diarrhea typically clears up within a few days after you stop taking the antibiotic.
How long does it take for clindamycin to get out of your system?
After oral administration of clindamycin hydrochloride, elimination half-life is increased to approximately 4.0 hours (range 3.4-5.1 h) in the elderly compared to 3.2 hours (range 2.1 – 4.2 h) in younger adults.
What are the symptoms of pseudomembranous colitis?
Signs and symptoms of pseudomembranous colitis may include:
- Watery diarrhea.
- Abdominal cramps, pain or tenderness.
- Fever.
- Pus or mucus in your stool.
- Nausea.
- Dehydration.
How long does diarrhea last after taking clindamycin?
Why does clindamycin cause diarrhea?
Many antibiotics, including clindamycin, may cause overgrowth of dangerous bacteria in the large intestine. This may cause mild diarrhea or may cause a life-threatening condition called colitis (inflammation of the large intestine).
How do you stop diarrhea when taking clindamycin?
To cope with diarrhea until your appointment, you can:
- Drink more water and other liquids to replace fluids lost because of diarrhea.
- Eat bland foods and avoid spicy or greasy foods that can aggravate diarrhea.
Can a person take antibiotics and get pseudomembranous colitis?
In some cases, taking antibiotics can cause C. diff to grow out of control and release toxins (poisons) into intestinal tissues. These toxins attack the lining of the intestine and cause pseudomembranous colitis symptoms.
How long does it take to show symptoms of pseudomembranous colitis?
In more severe cases, sepsis (the body’s potentially dangerous overreaction to an infection) can occur. Most people who have pseudomembranous colitis notice symptoms 5 to 10 days after starting treatment with antibiotics. How is pseudomembranous colitis diagnosed?
Are there any side effects after taking clindamycin?
Three days after starting oral clindamycin for the persistence of symptoms following a root canal, a 34-year-old male patient reported ” pimples ” on his scalp which changed to pustules 24 hours later. The lesions progressed and the patient’s antibiotic therapy was discontinued. Two days later, the rash improved considerably.
What kind of diarrhea can you get with clindamycin?
Clostridium difficile associated diarrhea (CDAD) has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild diarrhea to life-threatening colitis and has been observed to begin over 2 months after the administration of antibacterial agents.