How is Aloxi administered?

How is Aloxi administered?

The recommended dosage of ALOXI capsules in adults is 0.5 mg administered orally approximately one hour prior to the start of chemotherapy. ALOXI can be taken with or without food [see CLINICAL PHARMACOLOGY].

Are Aloxi and Zofran the same thing?

Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz. A brand name for palonosetron is Aloxi. Side effects of ondansetron and palonosetron that are similar include headache, constipation, dizziness, fatigue, and abnormal heart rate and rhythm.

How long does IV Aloxi last?

Palonosetron is a long acting medication that has a duration of action of 3 to 5 days. In most instances, only one dose needs to be given to prevent nausea and vomiting from chemotherapy.

Can palonosetron be given IV?

Postoperative Nausea and Vomiting The recommended adult dosage of Palonosetron HCl Injection is 0.075 mg administered as a single intravenous dose over 10 seconds immediately before the induction of anesthesia. Do not mix with other drugs. before administration.

How is palonosetron given?

Palonosetron injection comes as a solution (liquid) to be injected intravenously (into a vein) by a healthcare provider in a hospital or clinic. When palonosetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given as a single dose about 30 minutes before the start of chemotherapy.

When do you give a palonosetron?

It is recommended that palonosetron be given about 30 minutes before your dose of chemotherapy. If you are given this medication, you should not need to take ondansetron (Zofran) for 3–5 days after, since palonosetron works in a similar way for much longer.

Can Aloxi and Zofran be given together?

Interactions between your drugs Using ondansetron together with palonosetron can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.

How do you administer granisetron?

A dose of 1 – 3 mg (10 – 40 µg/kg) of Granisetron should be administered either as a slow intravenous injection or as a diluted intravenous infusion and administered over 5 minutes. The solution should be diluted to 5 ml per mg. Further maintenance doses of Granisetron may be administered at least 10 minutes apart.

How is palonosetron administered?

This medication is given by injection into a vein by a health care professional. It is given as directed by your doctor, usually 30 minutes before the start of chemotherapy or right before the start of surgery. The dosage is based on your medical condition and response to treatment.

When should I take Zofran after Aloxi?

If you received Aloxi, do NOT start to take Zofran until 24-36 hours after your treatment.

What should be the dosage of Aloxi injection?

ALOXI injection is supplied ready for intravenous administration at a concentration of 0.05 mg/mL (50 mcg/mL). Do not mix ALOXI injection with other drugs. Flush the infusion line with normal saline before and after administration of ALOXI injection.

How much palonosetron is in an Aloxi injection?

Aloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered solution for intravenous administration. Each 5-ml vial of Aloxi injection contains 0.25 mg palonosetron base as hydrochloride, 207.5 mg mannitol, disodium edetate and citrate buffer in water for intravenous administration.

What should be the dosage of Aloxi for PONV?

The recommended dosage of ALOXI injection in adults for PONV is 0.075 mg administered as a single intravenous dose over 10 seconds immediately before the induction of anesthesia. Instructions for Intravenous Administration ALOXI injection is supplied ready for intravenous administration at a concentration of 0.05 mg/mL (50 mcg/mL).

What to do if you mix Aloxi with other drugs?

Do not mix Aloxi injection with other drugs. Flush the infusion line with normal saline before and after administration of Aloxi injection. Inspect Aloxi injection visually for particulate matter and discoloration before administration. Discard unused portion. Aloxi injection is sterile, clear, and colorless solution: