Can drugs cause eosinophilic esophagitis?
Medications can induce esophageal abnormalities via both systemic effects and by causing direct esophageal mucosal injury. Systemic effects of medications that can result in esophagitis include gastroesophageal reflux and medication-induced infectious complications.
What medication causes direct esophageal mucosal injury?
Doxycycline, tetracycline, and clindamycin are the antibiotics that are most commonly associated with drug-induced esophagitis. These medications have a low pH when dissolved in solution, such as saliva, and cause transient esophageal injury that heals after withdrawal.
How is drug-induced esophagitis treated?
Treatment for drug-induced esophagitis is primarily avoiding the problem drug when possible and reducing the risk with better pill-taking habits. Your doctor may recommend: Taking an alternative drug that is less likely to cause drug-induced esophagitis. Taking a liquid version of a medication if possible.
How long does it take drug-induced esophagitis to heal?
Drug-induced esophagitis is usually a self-limiting disease and symptoms resolve within 10 days .
What drugs can cause eosinophilia?
Drug-induced eosinophilia
| Drug | Type of reaction |
|---|---|
| Cephalosporins | Various; cardiac, pulmonary and dermal reactions reported |
| Sulphonamides | Pulmonary and cardiac reactions reported |
| Tetracyclines, especially minocycline | Pulmonary reactions |
| Nitrofurantoin | Pulmonary reaction |
Why do bisphosphonates cause esophagitis?
When bisphosphonates bind, the hydrophobic barrier is destroyed, and gastric acid is able to reach the epithelium resulting in irritation. If bisphosphonates are taken properly, the rate of esophageal irritation is reduced.
What is drug-induced esophagitis?
Drug or pill-induced esophagitis is esophageal mucosal injury caused by the medications and usually refers to a direct toxic effect on esophageal mucosa by the culprit medication. Common symptoms include retrosternal pain, dysphagia, or odynophagia.
Can Humira cause eosinophilia?
Eosinophilia, elevated immunoglobulin E, and development of asthma has been reported in RA patients with the treatment of adalimumab.
Do bisphosphonates cause heartburn?
Oral bisphosphonates tend to be poorly absorbed by the body and can cause irritation of the gullet (heartburn), so it’s very important that you carefully follow the instructions for taking your medication: Take it on an empty stomach with a glass or two of plain tap water.
When was drug induced esophagitis first reported?
It was first reported in 1970 by Pemberton when a patient was found to have esophageal ulcers after taking potassium chloride tablets.[1][2] Drugs can be damaging to the esophageal wall by having a direct toxic effect on the esophageal mucosa, which produces a caustic effect by creating an acidic or alkaline environment.
Are there any drugs that can cause esophagitis?
Other antibiotics that can cause esophagitis include clindamycin, amoxicillin, metronidazole, ciprofloxacin, rifaximin, etc. Non-steroidal anti-inflammatory drugs (NSAIDs): aspirin and aceclofenac can lead to esophageal mucosal injury[3].
Is there a problem with drug induced eosinophilia?
Given that allergic reactions may result in eosinophilia, it would appear to be a potential problem with many drugs, as dictated by the idiosyncratic response of the individual patient. This paper concentrates on drugs that are reported to produce serious reactions, rather than mild or self-limiting drug induced eosinophilia.
What foods are most likely to cause eosinophilic esophagitis?
Eosinophilic esophagitis. In many cases, this type of esophagitis may be triggered by foods such as milk, eggs, wheat, soy, peanuts, beans, rye and beef. However, conventional allergy testing does not reliably identify these culprit foods.