Which medication has the highest risk for nephrotoxicity?
What drugs are the biggest offenders?
- Antibiotics. Either alone or in combination, vancomycin and piperacillin/tazobactam are both commonly used antibiotics in critically ill children for broad coverage, but are known to have nephrotoxic potential.
- Aminoglycosides.
- Chemotherapy.
- NSAIDs.
What drugs should be stopped in Aki?
All drugs which block renal excretion of potassium (trimethoprin and potassium sparing diuretics (spironolactone, amiloride) should be stopped. In addition, both beta-blockers and digoxin can inhibit the sodium / potassium ATPase pumps which move potassium inside cells.
Is Topamax nephrotoxic?
Topiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxicity.
Can Ambien mess up your kidneys?
Zolpidem (applies to Ambien) renal dysfunction Moderate Potential Hazard, Low plausibility. Zolpidem is extensively metabolized by the liver and subsequently excreted in the urine, primarily as metabolites.
What drugs can cause renal impairment?
Many medicines can cause acute kidney injury (which used to be called acute renal failure), such as:
- Antibiotics.
- Some blood pressure medicines.
- Medicines used for cancer treatment (chemotherapy).
- Dyes (contrast media).
- Illegal drugs.
- Medicines used to treat HIV.
- Non-steroidal anti-inflammatory drugs.
- Ulcer medicines.
Is AKI reversible?
Unlike kidney failure that results from kidney damage that gets worse slowly, AKI is often reversible if it is found and treated quickly. If you were healthy before your kidneys suddenly failed and you were treated for AKI right away, your kidneys may work normally or almost normally after your AKI is treated.
Can Topamax cause high creatinine?
The patient showed a significant, progressive increase in creatinine and serum urea values 5 days after topiramate treatment onset, as well as diminished creatinine clearance and non-oliguric acute renal failure requiring haemodialysis initiation. Upon topiramate discontinuance altered parameters became normal.
Is Topamax bad for your liver?
Topiramate is thought to be rarely associated with liver injury and by and large known to cause liver toxicity in conjunction with other anticonvulsants.
Is Ambien hard on the liver?
Zolpidem is a benzodiazepine receptor agonist that is used for the treatment of insomnia. Zolpidem has rarely been implicated in causing serum enzyme elevations and has not been reported to cause clinically apparent liver injury.
What is the most important information I should know about Topamax?
See “What is the most important information I should know about TOPAMAX®?” 1 High blood ammonia levels. High ammonia in the blood can affect your mental activities,… 2 Kidney stones. Drink plenty of fluids when taking TOPAMAX® to decrease your chances… 3 Low body temperature. Taking TOPAMAX® when you are also taking valproic acid can cause…
How often can you take Topamax in children?
Pediatric Patients 2 to 9 Years of Age. Dosing in patients 2 to 9 years of age is based on weight. During the titration period, the initial dose of TOPAMAX® is 25 mg/day nightly for the first week. Based upon tolerability, the dosage can be increased to 50 mg/day (25 mg twice daily) in the second week.
What’s the generic name for Topamax toe pyre a mate?
Topamax Generic Name: topiramate (toe PYRE a mate) Brand Name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR Medically reviewed by Sophia Entringer, PharmD.
Is it OK to eat a Topamax sprinkle capsule?
TOPAMAX ® Sprinkle Capsules may be swallowed whole or may be administered by carefully opening the capsule and sprinkling the entire contents on a small amount (teaspoon) of soft food. This drug/food mixture should be swallowed immediately and not chewed. It should not be stored for future use.