Which is the mechanism of action of Flucytosine?
Flucytosine is a pyrimadine analogue that has activity against fungal species by interfering with purine and pyrimidine uptake and by deaminated to 5-fluorouracil (5-FU) and then converted to 5-fluorodeoxyuridylic acid monophosphate, a noncompetitive inhibitor of thymidylate synthetase which interferes with DNA …
What drug class is Flucytosine?
Flucytosine is used to treat serious fungal infections in the body. It belongs to a class of drugs known as antifungal drugs. It is often used with other medications. It works by slowing the growth of certain types of fungus.
What is Flucytosine used to treat?
Flucytosine is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of serious infections caused by certain strains of two types of fungi: Candida and Cryptococcus.
What is the active form of Flucytosine?
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis….Flucytosine.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 2022-85-7 |
| PubChem CID | 3366 |
| DrugBank | DB01099 |
How flucytosine is metabolized?
Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism.
Is flucytosine an antimetabolite?
Flucytosine (5-fluorocytosine, 5-FC) is an antifungal agent originally developed in 1957 as an antimetabolite. Although it has found no role as an anti-tumor agent, it is used for the treatment of certain fungal infections.
Is Flucytosine a hazardous drug?
No known significant effects or critical hazards.
What are the adverse effects of Flucytosine?
Common side effects may include:
- nausea, vomiting, loss of appetite, diarrhea;
- headache, dizziness;
- numbness, tingling, or burning pain in your hands or feet;
- dry mouth; or.
- skin rash.
Is flucytosine a hazardous drug?
What are the adverse effects of flucytosine?
What is the rationale of combining amphotericin B and flucytosine?
The combination of amphotericin B at 0.5 mg/kg/day and flucytosine at 250 mg/kg/day was significantly more effective than monotherapies for reducing fungal burden in brain, spleen, and lungs after infection by the flucytosine-susceptible isolate and in brain and spleen for the flucytosine-resistant isolate.