What type of radiation does LU 177 emit?
Lu-177 emits β-rays that have a short range in soft tissue (average 0.23 mm, max. 1.7 mm) and γ-rays. The radionuclide is produced by the Lu-176(n,γ)Lu-177 reaction.
What is Lutetium Lu 177 used for?
Lutetium Lu 177 dotatate is a radioactive medicine that binds itself to a specific part of certain tumor cells, allowing the radiation to enter and destroy those cells. Lutetium Lu 177 dotatate is used to treat certain cancers of the digestive tract, including the stomach, pancreas, and intestines.
What is the half-life of Lu 177?
Lu-177 has a half-life of 6.7 days and is delivered in a similar manner as other beta-emitting therapy parenteral administrations. Lu-177 has a short penetration radius, which makes it suitable for radioimmunotherapy for smaller tumors like GEP-NETs.
What particle is emitted when lutetium 177 is emitted?
Lu 177 emits high energy beta particles with an Eβ max = 497 keV (78.6 %), 384 keV (9.1 %) and 176 keV (12.2 %), and gamma photons Eγ = 208keV (11.1%), 113 keV (6.6%). There are also multiple low energy x-rays (65 keV or less), but emitted a small percent of time.
What is Lu therapy?
Lutetium Lu 177 dotatate, a peptide receptor radionuclide therapy (PRRT), is a tumor-targeted treatment that uses radiation to induce tumor cell death in neuroendocrine tumors (NETs) via a β particle-emitting radionuclide linked to a somatostatin peptide analog.
What is the half-life of y90?
Yittrium-90 is a pure beta-emitter, with a decay energy of 0.94 MeV and the average penetration depth in human tissue is 2.4 mm. In the form of microspheres, it is suitable for selective arterial injection. The physical half-life of Y-90 is 64.2 h.
What is lutetium used for in everyday life?
Lutetium is used in research. Its compounds are used as hosts for scintillators and X-ray phosphors, and the oxide is used in optical lenses. The element behaves as a typical rare earth, forming a series of compounds in oxidation state +3, such as lutetium sesquioxide, sulfate, and chloride.
Is Lu an isotope?
Naturally occurring lutetium (71Lu) is composed of one stable isotope 175Lu (97.41% natural abundance) and one long-lived radioisotope, 176Lu with a half-life of 3.78 × 1010 years (2.59% natural abundance). The isotopes of lutetium range in atomic weight from 149.973 (150Lu) to 183.961 (184Lu). …
What PSMA 617?
Lu-PSMA-617 is an investigational PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer. It is a type of precision cancer treatment combining a targeting compound (ligand) with a therapeutic radioisotope (a radioactive particle)11-13.
Where is lutetium 177 produced?
Shine is also pursuing the ability to create its own Yb-176 starting material. Lu-177 is one of a variety of medical radioisotopes that Shine intends to produce at its US medical isotope production facility in Janesville, Wisconsin, where a groundbreaking ceremony took place on 9 May.
How is lutetium-177 created?
The 177Lu production processes are based on irradiation of isotopically enriched 176Lu or 176Yb with reactor neutrons, followed by radiochemical processing of the irradiated targets. Specific production features are analyzed with emphasis on process aspects of the reactor and radiochemical stages.