What species are C57BL 6 mice?
C57BL/6, often referred to as “C57 black 6”, “C57” or “black 6”, is a common inbred strain of laboratory mouse. It is the most widely used “genetic background” for genetically modified mice for use as models of human disease.
Are male mice more aggressive than female mice?
Aggression and sexual behaviour are controlled by the same brain cells in male mice – but not in females. The finding suggests that males are more likely to become aggressive when they see a potential mate than females. Similar to humans, male mice are, on the whole, more aggressive than females.
How are C57BL / 6J and c57nj mice different?
C57BL/6J and C57BL/6NJ mice exhibit a variety of physiological and phenotypic differences; and small nucleotide polymorphisms, in-frame deletions, and structural variants affecting coding regions that differentiate C57BL/6J and C57BL/6NJ strains have been identified and validated ( Simon et al., 2013 ).
Where did the C57BL / 6N substrain come from?
The NIH substrain, C57BL/6N, was later distributed to several institutes including Charles River Laboratories in 1974 (C57BL/6NCrl), to Harlan (now Envigo, C57BL/6NHsd) in 1974 and 1988, and to Taconic (C57BL/6NTac) in 1991. In 2005, the N substrain came back to The Jackson Laboratory, and is known as the C57BL/6NJ substrain.
Where is the sequence variant located in C57BL / 6nj?
A sequence variant is identified in C57BL/6N (C) as compared to C57BL/6J (T) at position 3,222,537 (GRCm38). The polymorphism is located in the C-terminal leucine-rich repeat domain and results in a lysine to arginine change at amino acid residue 1034 (p.K1034R).
Who was the creator of the C57BL / 6 mouse?
C57BL/6 substrain history. The original C57BL/6 mouse was created by Clarence Cook Little, founder of The Jackson Laboratory, in 1921. Since that time, the strain has been distributed to hundreds of institutes and thousands of laboratories worldwide.