What is the teratogenic effect of isotretinoin?
Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal abnormalities including cleft lips, ear and eye defects, and mental retardation.
How does isotretinoin affect pregnancy?
Maternal use of synthetic vitamin A (retinoids) such as isotretinoin (Accutane) during pregnancy can result in multiple effects on the developing embryo and fetus including miscarriage, premature delivery and a variety of birth defects.
What birth defects are caused by isotretinoin?
Birth defects caused by isotretinoin include:
- Cleft palate and other birth defects of the face.
- Congenital heart defects.
- Ear problems.
- Eye problems.
- Microcephaly.
- Problems with the thymus gland.
- Problems with the parathyroid glands.
What is teratogenic action?
Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs.
Can Accutane cause birth defects later in life?
“Accutane-exposed pregnancies continue to occur and result in babies with major birth defects,” Honein tells WebMD.
Does isotretinoin have long term side effects?
The more serious side effects of isotretinoin can have long-term or permanent effects. However, apart from increased cholesterol and joint and muscle problems, these side effects are all quite rare.
What drugs cause teratogenic effects?
Teratogenic drugs and birth defects
- ACE (angiotensin converting enzyme) inhibitors.
- angiotensin II antagonist.
- isotretinoin (an acne drug)
- alcohol.
- cocaine.
- high doses of vitamin A.
- lithium.
- male hormones.
What do teratogenic drugs cause?
Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect).
What kind of factors influence if an exposure could be teratogenic?
Environmental Factors and Birth Defects The effects depend on the nature of the teratogen, the timing at which the exposure occurs and, most likely, the genetic susceptibility of the mother and/or the fetus. Teratogenic agents can be environmental chemicals, maternal metabolic factors, drugs, or infections.
What is the teratogenicity of isotretinoin revisited?
Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid This paper reviews the teratogenicity of isotretinoin in regard to aspects of species variation, toxicokinetics, and metabolism.
Are there long-term effects of isotretinoin in pregnancy?
Possible long-term teratogenic effect of isotretinoin in pregnancy The isotretinoin, a 13-cis-retinoic acid, has revolutionized the management of severe treatment-resistant acne and it has been widely used for a range of dermatological conditions, in 90% of the time in young women between 13 and 45 years of age.
How is isotretinoin used in the treatment of acne?
Abstract The isotretinoin, a 13-cis-retinoic acid, has revolutionized the management of severe treatment-resistant acne and it has been widely used for a range of dermatological conditions, in 90% of the time in young women between 13 and 45 years of age.
How does isotretinoin affect the central nervous system?
Isotretinoin (Accutane) as a Teratogen. Such disruptions can lead to developmental defects, particularly in the embryonic spinal cord, central nervous system, and spinal cord, where retinoic acid synthesizes and where catabolic enzymes are located.