What is the formula for calculating GFR?
| Race | Sex | Equation (age in years for ≥ 18) |
|---|---|---|
| White or other | Female | GFR = 144 × (Scr/61.9)-0.329 × (0.993)Age |
| White or other | Female | GFR = 144 × (Scr/61.9)-1.209 × (0.993)Age |
| White or other | Male | GFR = 141 × (Scr/79.6)-0.411 × (0.993)Age |
| White or other | Male | GFR = 141 × (Scr/79.6)-1.209 × (0.993)Age |
How is cystatin C measured?
Methods: Serum and urinary cystatin C levels were measured by using an enzyme-linked immunosorbent assay (ELISA) method, 24-hour creatinine clearance was used as an indicator of GFR. Results: Reference intervals with 95% ranges are 0.47-1.03 mg/l in the serum from healthy volunteers.
What is the importance of cystatin C as a marker for GFR?
Cystatin C is effectively filtered by the glomerulus and fully reabsorbed and broken down by the renal tubules for recycling. A raised level of serum or plasma cystatin C correlates closely with the GFR. Cystatin C therefore acts as an excellent indicator of reduced kidney function.
Is cystatin a C?
Cystatin C is a protein that is produced by the cells in your body. When kidneys are working well, they keep the level of cystatin C in your blood just right. If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well.
What is serum cystatin C?
Serum cystatin C is a non-glycosylated, 13.3-kDa protein belonging to cystatin protease inhibitors. It has shown promise as a replacement for serum creatinine in estimation of GFR. [4,5] After glomerular filtration, it is fully catabolized in the proximal renal tubule and is not returned to blood.
What is cystatin C normal range?
The normal range of cystatin C is around 0.62 – 1.15 mg/L. Values can vary between laboratories. Generally, higher cystatin C levels point to poor kidney function [7].
How is cystatin C produced?
Cystatin C (CysC) is a cysteine proteinase inhibitor71 produced by nucleated cells and coded by a housekeeping gene. CysC is freely filtered by the glomerulus and then reabsorbed by the proximal tubules, where it is catabolized.
What is the function of cystatin C?
Cystatin C is an endogenous cysteine proteinase inhibitor of low molecular weight that possesses many ideal features for use as a surrogate marker of kidney function and an estimate of GFR. Cystatin C is synthesized at a relatively constant rate and is released into plasma by all nucleated cells in the body.
What is cystatin C function?
What is cystatin C NCBI?
Cystatin C, first described in 1961 and formally named in 1984, is a non-glycosylated, basic protein encoded by the CST3 gene that is found in virtually all nucleated cells. Cystatin C is generated at a mostly constant rate, is freely filtered, reabsorbed and catabolized in the proximal tubule of the nephron2.
What is estimated glomerular filtration rate?
GFR is reported in milliliters per minute per 1.73 m2, which is the average surface area of an adult. The normal value for glomerular filtration rate is about 120 to 130 ml/min/1.73 m2.
What is the equation for creatinine clearance?
Cockcroft and Gault equation utilizing the ibw (Ideal body weight) to calculate an estimated creatinine clearance. Estimate Ideal body weight in (kg) Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet. Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.
How is glomerular filtration calculated?
Glomerular filtration rate ( GFR ) can be calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys. The rate therefore measured is the quantity of the substance in the urine that originated from a calculable volume of blood.
What affects glomerular filtration rate?
Heart disease is the major cause of death for all people with CKD. Glomerular filtration rate (GFR) is the best estimate of kidney function. Hypertension causes CKD and CKD causes hypertension. Persistent proteinuria (protein in the urine) means CKD is present.