What is the expected pharmacological action of alprazolam?
The exact mechanism of action of alprazolam is unknown. Benzodiazepines bind to gamma aminobutyric acid (GABA) receptors in the brain and enhance GABA-mediated synaptic inhibition; such actions may be responsible for the efficacy of alprazolam in anxiety disorder and panic disorder.
Can alprazolam raise your blood pressure?
The bottom line. Xanax is used to treat anxiety and panic disorders. It slows down central nervous system activity, which can lead to a temporary drop in blood pressure. Xanax may also lower your blood pressure over the long term, although taking this medication on a regular basis isn’t recommended.
Does alprazolam have active metabolites?
Metabolism/Elimination Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam and α hydroxyalprazolam. A benzophenone derived from alprazolam is also found in humans.
How is alprazolam excreted?
Alprazolam and its metabolites are filtered out by the kidneys and excreted in the urine. The mean plasma half-life of alprazolam is about 11.2 hours in healthy adults.
Are there any serious side effects of alprazolam?
Serious adverse reactions of alprazolam (Xanax) include: Side effects of alprazolam (Xanax) from postmarketing reports: This document does not contain all possible side effects and other serious side effects may occur.
How does alprazolam work on the central nervous system?
Alprazolam is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA). How to use alprazolam oral
When does alprazolam peak in the plasma?
Absorption Following oral administration, alprazolam is readily absorbed. Peak concentrations in the plasma occur in 1 to 2 hours following administration. Plasma levels are proportionate to the dose given; over the dose range of 0.5 to 3.0 mg, peak levels of 8.0 to 37 ng/mL were observed.
What is the DEA code number for alprazolam?
Alprazolam (DEA Code Number: 2882) is a Schedule IV controlled substance. Schedule IV Controlled Substance: (A) The drug or other substance has a low potential for abuse relative to the drugs or other substances in schedule III.