What is sublingual GTN?
Spray, sublingual tablets (for under the tongue), ointment and patches. Glyceryl trinitrate (GTN) is prescribed for chest pain associated with angina. Tablet and spray formulations are referred to as short-acting preparations. This is because the effect of the medicine lasts for around 20-30 minutes.
What is GTN in pharmacology?
Nitroglycerin, also known as glyceryl trinitrate (GTN), is a medication used for heart failure, high blood pressure, anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart (angina) or due to the recreational use of cocaine.
What is the advantage of giving GTN sublingually?
Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.
Why is GTN administered sublingually and not orally?
Glyceryl trinitrate (or nitroglycerin) undergoes extensive hepatic presystemic metabolism when given orally. Therefore, it is usually given by the sublingual route, by which it is well absorbed and rapidly taken up into the circulation.
What does GTN stand for?
Glyceryl Trinitrate
GTN
| Acronym | Definition |
|---|---|
| GTN | Glyceryl Trinitrate |
| GTN | Greater Talent Network (speakers bureau; New York, NY) |
| GTN | Global Technology Network |
| GTN | Germantown (Maryland) |
How do you take sublingual GTN?
How to take GTN tablets
- Sit down.
- Put a tablet under your tongue and close your mouth.
- Allow the tablet to dissolve slowly – do not suck, chew or swallow it.
- Close the container – this is important, so your tablets do not lose their strength.
- Rest for a while, then stand up slowly.
What is the role of GTN?
Glyceryl trinitrate, or GTN, is a type of medicine called a nitrate. It is used to treat angina (chest pain). It can help stop chest pain if an angina attack has already started. It can also help to prevent them from starting.
What is the mechanism of action of GTN?
Glyceryl Trinitrate is a vasodilating agent. Its principle pharmacological action is the relaxation of vascular smooth muscle. Glycerol Trinitrate produces, in a dose related manner, dilation of both arterial and venous beds.
When is GTN contraindicated?
Nitroglycerin is contraindicated in patients that have reported allergic symptoms to the medication. [18] Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerin are contraindications to nitroglycerin therapy.
How is sublingual medication administered?
Sublingual administration delivers a medication across mucous membranes in the mouth either under the tongue or inside the cheek. Because the oral mucosa has a thin epithelium and abundant blood vessels, many medications administered here are rapidly absorbed.
Why is sublingual more effective?
One reason for selecting the sublingual route is to avoid drug destruction. Because gastric acid and intestinal and hepatic enzymes are bypassed, sublingual absorption can be more efficient overall for certain drugs than intestinal uptake. The onset of drug effect may also be quicker than with oral ingestion.
What group of drugs does GTN belong to?
Glyceryl trinitrate belongs to a group of medicines called nitrates that relax the muscle walls of the blood vessels and reduce the workload of the heart. GTN Spray is used to treat angina at the onset of an attack.
How to store glyceryl trinitrate sublingual tablets?
How to store glyceryl trinitrate. Store GTN sublingual tablets in their original container. They can be used for up to eight weeks after the container has been opened. After this time, get a fresh supply. Keep all medicines out of the reach and sight of children. Store in a cool, dry place, away from direct heat and light.
Which is a characteristic of the pharmacokinetics of GTN?
The pharmacokinetics of GTN associated with various dose regimens are characterised by prominent intra- and inter-individual variability. It is, nevertheless, important to clearly understand the pharmacokinetics and characteristics of GTN to optimise its use in clinical practice and, in particular, to obviate the development of tolerance.
Can a GTN regimen be used in clinical practice?
Efforts are warranted to circumvent the development of tolerance and facilitate the use of GTN in clinical practice. Although this remains to be accomplished, it is likely that, in the near future, regimens will be developed based on a full understanding of the pharmacokinetics and pharmacodynamics of GTN and its metabolites.
How is tolerance related to metabolism of GTN?
The development of tolerance is closely related to the metabolism of GTN, and can be broadly categorised as haemodynamic tolerance versus vascular tolerance. Efforts are warranted to circumvent the development of tolerance and facilitate the use of GTN in clinical practice.