What is Pasireotide used for?
Pasireotide is used to treat Cushing’s disease or acromegaly (endocrine disorders). Pasireotide is usually given after surgery or other treatments did not work or have stopped working.
What are the long term effects of acromegaly?
ACTIVE ACROMEGALY IS associated with complaints such as fatigue, joint pains, headache, paresthesias, and excessive perspiration. GH and IGF-I excess are also associated with an increased incidence of diseases including diabetes mellitus, hypertension, obesity, obstructive sleep apnea syndrome, and heart disease (1–5).
Does Pasireotide act on the pituitary gland?
Pasireotide is a novel pituitary-directed drug, a SST analog with a broad range of effects on almost all SSTRs, that has recently been approved for use in adult patients with CD.
How does Pasireotide work in Cushing’s disease?
Pasireotide (Signifor) is a somatostatin analog that binds and activates human somatostatin receptors resulting in inhibition of ACTH secretion, which leads to decreased cortisol secretion. It is indicated for treatment of adults with Cushing disease in whom pituitary surgery is not an option or has not been curative.
Who is at risk for acromegaly?
Acromegaly is usually diagnosed in adults aged 30 to 50, but it can affect people of any age. When it develops before the end of puberty, it’s known as “gigantism”.
Is acromegaly curable?
Acromegaly is treatable in most people. But because symptoms come on slowly, health problems can develop before the disorder is diagnosed and treated.
What body parts does acromegaly affect?
Acromegaly is a disorder that occurs when your body makes too much growth hormone (GH). Produced mainly in the pituitary gland, GH controls the physical growth of the body. In adults, too much of this hormone causes bones, cartilage, body organs, and other tissues to increase in size.
Which age group does acromegaly most commonly affect?
Acromegaly can develop in people of any age but usually affects adults between the ages of 30 and 50. If acromegaly occurs in children it causes gigantism, where the skeleton grows very quickly as an excessive amount of growth hormone is released by the pituitary tumor.
Is Metyrapone a corticosteroid?
Metyrapone is an Adrenal Steroid Synthesis Inhibitor.