What is hydroxypropyl beta cyclodextrin?
2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a chemically modified cyclic oligosaccharide produced from starch that is commonly used as an excipient. Although HP-β-CD has been suggested as a potential adjuvant for vaccines, its immunological properties and mechanism of action have yet to be characterized.
Is 2-hydroxypropyl-β-cyclodextrin safe?
HP-beta-CD has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date.
What medications contain 2-hydroxypropyl-β-cyclodextrin?
2 Hydroxypropyl Beta Cyclodextrin
- Sertraline.
- Bioavailability.
- Ampakine.
- Cyclodextrin.
- Aqueous.
- Itraconazole.
- Cholesterol.
- Complex Formation.
What is 2 hydroxypropyl cyclodextrin?
Product Description. 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.
Is 2 hydroxypropyl cyclodextrin Hbcd safe?
What does 2-hydroxypropyl-β-Cyclodextrin do?
In particular, 2-hydroxypropyl-β-cyclodextrin (HPβCD) has garnered attention because of its cholesterol chelating properties, which appear to treat a rare neurodegenerative disorder and to promote atherosclerosis regression related to stroke and heart disease.
Is 2-hydroxypropyl-β-Cyclodextrin safe?
What is the chemical formula for beta cyclodextrin?
beta-CYCLODEXTRIN PubChem CID 444041 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula (C6H10O5)7 or C42H70O35 Synonyms beta-CYCLODEXTRIN Betadex Cyclomaltohept
Which is more toxic 2-hydroxypropyl-β-cyclodextrin?
2-hydroxylpropyl-β-cyclodextrin (HP-β-CD), a hydroxyalkyl derivative, is an alternative to α-, β- and γ-cyclodextrin, with improved water solubility properties (Uekama et al., 1998, Yoshida et al., 1988) and may be slightly more toxicologically benign.
How many glucopyranosyl units are in beta cyclodextrin?
All Rights Reserved. Beta-cyclodextrin is a non-reducing cyclic saccharide consisting of seven α-1,4-linked D-glucopyranosyl units.
What is the solubility of cyclodextrin in water?
The solubility of natural cyclodextrins is very poor. In the late 1960′s, it was discovered that chemical substitutions at the 2, 3, and 6 hydroxyl sites would greatly increase solubility. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.