What is HUWE1 gene?
HUWE1 (HECT, UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with HUWE1 include Intellectual Developmental Disorder, X-Linked, Syndromic, Turner Type and Syndromic X-Linked Intellectual Disability Turner Type.
What is the role of HUWE1 in the ubiquitin system?
HUWE1 is a universal quality-control E3 ligase that marks diverse client proteins for proteasomal degradation. Although the giant HECT enzyme is an essential component of the ubiquitin–proteasome system closely linked with severe human diseases, its molecular mechanism is little understood.
What is the full length structure of HUWE1?
The full-length structure of HUWE1 reveals the bipartite organization of the giant E3 ubiquitin ligase, which is composed of a catalytic HECT domain and a large, ring-shaped scaffold defining substrate specificity and E3 activity.
What is the function of HUWE1 in the proteome?
Moreover, it is increasingly clear that HUWE1 also has a general protein quality-control function, whereby it corrects proteome imbalances by acting in the unassembled soluble protein-degradation pathway 19.
What is the function of HUWE1 E3 ligase?
Cited for: FUNCTION. “HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKalpha.” “Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.” “High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.”
https://www.youtube.com/watch?v=8rbbU8fJFig