What is an example of antagonistic pleiotropy?
An example of this is testosterone levels in male humans. Higher levels of this hormone lead to increased fitness in early life, while causing decreased fitness in later life due to a higher risk for prostate cancer. This is an example of antagonistic pleiotropy being an explanation for senescence.
What is pleiotropy in simple words?
Definition of pleiotropy genetics. : the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic In genetics, there’s a concept called pleiotropy, which posits that a single gene can influence multiple traits. [
What causes antagonistic pleiotropy?
Antagonistic pleiotropy arises when alleles that have beneficial effects on one set of fitness components also have deleterious effects on other fitness components.
Is Sickle cell Anemia antagonistic pleiotropy?
The remarkable sustained prevalence of a number of disease-associated alleles is therefore surprising. We believe that antagonistic pleiotropy, when multiple effects of a gene have opposing effects on fitness (e.g., sickle cell disease), may be more widespread than typically considered.
What is meant by Pleiotropism give two examples?
Pleiotropism is the condition in which a single gene controls more than one phenotypic effect, that is completely unrelated. E.g.: Phenylketonuria. It is an autosomal recessive disorder affecting chromosome number 12.
What is pleiotropy Slideshare?
Introduction • Defination- Pleiotropism is defined as when one gene influences multiple, unrelated phenotypic traits • Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits • Mutation in a pleiotropic gene may have an effect on some or all traits • Mechanism of pleiotropy in most cases …
What is homogeneous in genetics?
In biology, a homogenous population refers to the population wherein the individuals essentially have the same genetic constitution brought about by certain modes of asexual reproduction. The offspring produced via asexual reproduction are homogenous as they are identical to each other, including their parents.
Is antagonistic pleiotropy ubiquitous in aging biology?
Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years ago to be the genetic trade-off between early life fitness and late life mortality. These tradeoffs, known as antagonistic pleiotropy, are common, perhaps ubiquitous.