What is adapalene and clindamycin phosphate gel used for?
Adapalene + Clindamycin is a combination of two medicines: Adapalene and Clindamycin, which treats pimples (acne). Adapalene is a form of vitamin A which prevents accumulation of the sebum (skin’s natural oil), unblocks the pores and allows natural exfoliation of the outer layers of skin.
Is adapalene or clindamycin better for acne?
Conclusions: Adapalene is as efficacious as benzoyl peroxide-clindamycin combination to treat mild to moderate acne vulgaris, but it is comparatively better tolerated than benzoyl peroxide-clindamycin combination.
Is clindamycin safe for face?
Clindamycin is only safe for use on your skin. Make sure to avoid getting the medication close to or in your eyes, nose, mouth or areas with broken skin. If you accidentally apply clindamycin to these areas, make sure to rinse them thoroughly using cool water.
Is adapalene safe to use?
The maximal use trial, a study of absorption of the drug through acne-affected skin when applied daily over a large surface area (face, shoulders, upper back and chest), demonstrated that absorption is limited, thus supporting safe use of Differin Gel 0.1% by people using it OTC.
What is clindamycin good for?
Clindamycin is used to treat certain types of bacterial infections, including infections of the lungs, skin, blood, female reproductive organs, and internal organs. Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria.
What are the side effects of adapalene gel?
A brief sensation of warmth or stinging may occur right after applying the medication. Skin redness, dryness, itching, scaling, mild burning, or worsening of acne may occur during the first 2-4 weeks of using the medication. These effects usually decrease with continued use.
What are the effects of topical adapalene and clindamycin?
Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris The efficacy of combined therapy with a retinoid and antibiotic for Japanese patients with acne vulgaris remains to be established.
What is the chemical name of adapalene gel?
The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. Adapalene is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is C 28H 28O 3 and molecular weight is 412.52.
How often does clindamycin phosphate gel need to be applied?
Sixty-six patients were recruited. The regimen comprised two phases. For the 4-week initial treatment, 1% clindamycin phosphate gel was applied twice daily and 0.1% adapalene gel, once.
Which is better for acne adapalene gel or vehicle?
Clinical studies. The results of this study demonstrated that adapalene gel 0.3% was superior to adapalene 0.1% gel and vehicle in moderate to moderately severe acne while retaining a similar study and tolerability profile to adapalene 0.1% gel ( Pariser et al 2005 ).