What does the FXR1 protein do?
FXR1 Regulates Abundance and mRNA Stability of Pro- inflammatory mRNA and Protein Literature on FXR1 function is inconsistent and appears to be cell type specific.
How does the FXR1 protein interact with the mRNAs?
FXR1 binds canonical and non-canonical sequences in the 3′ UTR of TNFalpha. FXR1 interacts with HuR via mRNA tethering on the 3′ UTR of inflammatory transcripts. The expression of downstream processes corroborates active PPARalpha signaling in LSECs.
What is the function of the FMR1 gene?
The FMR1 gene provides instructions for making a protein called FMRP. This protein is present in many tissues, including the brain, testes, and ovaries. In the brain, it may play a role in the development of connections between nerve cells (synapses), where cell-to-cell communication occurs.
What is the closest protein coding gene to the right of FMR1 on the chromosome?
FMR1 (fragile X mental retardation 1) is a human gene that codes for a protein called fragile X mental retardation protein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function….FMR1.
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What is the effect of IL 19 on FXR1 gene expression?
IL-19 Induces FXR1 Expression in VSMCs. IL-19 is anti-proliferative for VSMCs and reduces inflammatory transcript mRNA stability (Tian et al., 2008). Stimulation of VSMCs with IL-19 significantly induces FXR1 mRNA and protein expression (Figures 7A–7C).
Where is FMR1 gene located?
FMR1 is located on the X-chromosome and encodes the fragile X mental retardation protein (FMRP). FMRP has been shown to bind mRNA and regulate translation of specific synaptic proteins.
How long is the FMR1 gene?
Fragile X Mental Retardation gene, FMR1 3 spaning approximately 40 kb of genomic sequence (1). The FMR1 gene contains 17 exons and its mRNA is ~ 4 kb long.
How does change in amino acid sequence affect protein function?
The gene, or sequence of DNA, ultimately determines the unique sequence of amino acids in each peptide chain. A change in nucleotide sequence of the gene’s coding region may lead to a different amino acid being added to the growing polypeptide chain, causing a change in protein structure and therefore function.
How are amino acids categorized?
Based on the variable group, amino acids can be classified into four categories: nonpolar, polar, negatively charged, and positively charged. Of the set of twenty amino acids, eleven can be made naturally by the body and are termed nonessential amino acids.
What does mRNA do in protein synthesis?
Messenger RNA (mRNA) molecules carry the coding sequences for protein synthesis and are called transcripts; ribosomal RNA (rRNA) molecules form the core of a cell’s ribosomes (the structures in which protein synthesis takes place); and transfer RNA (tRNA) molecules carry amino acids to the ribosomes during protein …
What are the diseases associated with the FXR1 gene?
FXR1 (FMR1 Autosomal Homolog 1) is a Protein Coding gene. Diseases associated with FXR1 include Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures and Myopathy, Congenital Proximal, With Minicore Lesions . Among its related pathways are HIV Life Cycle and Oncogenic MAPK signaling .
Can a cancer cell survive without the FXR2 gene?
Cancer cells survive without FXR2 because a similar gene, called FXR1, can compensate. Fan et al. therefore decided to experimentally lower the activity of the FXR1 gene and, as expected, cancer cells without TP53 and FXR2 stopped growing. Normal cells, on the other hand, were unaffected by the deletion of the FXR1 gene since FXR2 is still there.
Where are FMR1 and FXR2 proteins located?
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit.
What is the function of the transcription factor FXR1?
Mechanistically, in addition to its RNA-binding function, FXR1 recruits transcription factor STAT1 or STAT3 to gene promoters at the chromatin interface and regulates transcription thus, at least partially, mediating cell proliferation.