What does protodioscin do?
Traditionally, this plant has been used for relieving cough and asthma; eliminating rheumatic aches; alleviating pain; and improving blood circulation. Saponins [protodioscin (102), methylprotodioscin (103), dioscine (104)] (Fig. 4.14) are the major constituents of this herb having antidiabetic activity.
What is pseudo Protodioscin?
102115-79-7. Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
How long should you take Tribulus terrestris?
When taken by mouth: Tribulus is possibly safe for most people when taken at doses of 750-1500 mg daily for up to 90 days. Side effects are usually mild and uncommon, but might include stomach pain, cramping, and diarrhea.
Is Protodioscin a saponin?
Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella Dioscorea and Trillium families. It is best known as the putative active component of the herbal aphrodisiac plant Tribulus terrestris.
When should I take tribulus?
Best Time to Take Tribulus Tribulus is best absorbed on an empty stomach, and it is commonly taken in a single daily dose half an hour before a meal. Ideally it should be taken around the same time daily. Most important with Tribulus is you don’t miss a day.
Does Tribulus work bodybuilding?
And although it doesn’t increase testosterone, Tribulus terrestris may improve libido in men and women. However, it won’t improve body composition or exercise performance. While most research shows that this supplement is safe and causes only minor side effects, there have been isolated reports of toxicity.
Can tribulus cause blood clots?
You are taking clopidogrel: Tribulus may increase the risk of blood clots. Stent thrombosis has been reported in patients following concurrent use of clopidogrel and an herbal formula containing tribulus.
Can you take tribulus and ashwagandha together?
Users of Tribulus for bodybuilding report that the best results are obtained when it is combined with other testosterone boosting herbs such as Ashwagandha. Said to give the “strength of a stallion”, Ashwagandha significantly raises serum testosterone levels by (again) increasing the luteinising hormone (LH).
Does Tribulus increase androgen receptors?
While it is not exactly known how tribulus works, it is known to enhance androgen receptor density in the brain (muscle tissue not confirmed) which may enhance the libido enhancing properties of androgens. Limited evidence suggests that it is weak to non-effective in enhancing fertility.
What is the role of protodioscin in plants?
Anoop Kumar, in Recent Advances in Natural Products Analysis, 2020 Steroidal saponin (e.g., protodioscin) and triterpenoid saponin (e.g., ginsenosides) are the main groups of saponin showing various roles in plants. They act as an antimicrobial, prevent mold growth, and protect plants from insect attack.
Where is protodioscin located in the glycoside chain?
Protodioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha – (1->4)- [ alpha-L-Rha – (1->2)]- beta-D -Glc attached to position 3 of 26- (beta-D-glucopyranosyloxy)-3beta,22-dihydroxyfurost-5-ene via a glycosidic linkage. Found in several plant species including yams, asparagus and funugreek.
How much protodioscin can you take in a day?
The average content of protodioscin in DR is 0.183%, and so the dose of protodioscin for rats is 4.76 mg/kg/day. Therefore, the 5 mg/kg/day is as low dose, and 10 mg/kg/day is as high dose in this study.
What kind of cell death does protodioscin cause?
Protodioscin from fenugreek (Trigonella foenumgraecum) induced cell death in the leukemic cell line HL-60 by apoptosis while the gastric cancer cell line KATO III was merely inhibited with no apoptosis observed thus demonstrating cell line-dependent results [24].