What does HTRA1 stand for?
HTRA1 (HtrA Serine Peptidase 1) is a Protein Coding gene. Diseases associated with HTRA1 include Cerebral Arteriopathy, Autosomal Recessive, With Subcortical Infarcts And Leukoencephalopathy and Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 2.
What is the function of serine proteases?
Serine proteases are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the active site.
Why are they called serine proteases?
They are called the serine proteases for two reasons: They hydrolyze proteins. They have an essential Ser residue at the active site which is critical for catalysis. In fact this Ser is much more reactive then other serines in the protein.
What does a serine protease do?
What do serine protease do?
What kind of protein is the HTRA1 gene?
From Wikipedia, the free encyclopedia Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin -like peptidase domain and a PDZ domain.
What is the role of HTRA1 in the extracellular matrix?
The HTRA1 enzyme helps break down many other kinds of proteins in the space surrounding cells (the extracellular matrix). The HTRA1 enzyme also attaches (binds) to proteins in the transforming growth factor-beta (TGF-β) family and slows down (inhibits) their ability to send chemical signals.
Is the HTRA1 gene related to macular degeneration?
Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.