What does homozygous for C677T mean?
Approximately 5-14% of the U.S. population is homozygous for C677T, meaning that they have two copies of it.
How common is homozygous C677T?
In the United States, ≈20% to 40% of white and Hispanic individuals are heterozygous for MTHFR C677T. The mutation is less common in blacks (1%–2%). In North America, Europe, and Australia, ≈8% to 20% of the population have 2 MTHFR C677T mutations, that is, they are homozygous.
What foods should you avoid with MTHFR?
People with MTHFR mutations may want to avoid foods that contain the synthetic form of folate, folic acid — though the evidence is not clear that’s necessary or beneficial. Be sure to check labels, as this vitamin is added to many enriched grains, like pasta, cereals, breads, and commercially produced flours.
How is MTHFR C677T treated?
Summary: Patients with the MTHFR C677T mutation have a reduced ability to convert folic acid into its active form, L-methylfolate. Both L-methylfolate and folic acid are possible treatment options for these patients. However, there are currently no guidelines regarding dosage of folic acid or L-methylfolate.
Can MTHFR cause blood clots?
Some individuals with a MTHFR mutation have elevated homocysteine levels. Elevated homocysteine levels may cause irritation of the blood vessels and are considered a risk factor for blood clots. Individuals with MTHFR mutations who have normal homocysteine levels are not at increased risk for clots.
What is the difference between MTHFR c1298c and C677T?
MTHFR C1298C = homozygous mutation (two mutations) MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation One of the biggest concerns for those with an MTHFR mutation is the effect it may have on homocysteine levels in the blood.
Can a mutation in MTHFR be written t677t?
Heterozygous mutations are MTHFR C677Tbecause there is one normal C and one abnormal T. Also occasionally written 677CT. Homozygous C677T can also be written as T677T(because there are two abnormal copies with T instead of C). Occasionally you’ll also see it written 677TT Phew!
What does compound heterozygous mean in MTHFR mutation?
There is also compound heterozygous, which is when you have one mutant allele on both the 677 and 1298 base position. Summary: In genetics, hetero- and homo- refers to the two alleles (letters) on the gene. A heterozygous mutation means one copy of the mutation, homozygous means two copies. List of Common MTHFR Mutation Variations
What’s the difference between homocysteine and C677T?
Research shows that regardless of how much folate you consume, homozygous C677T (T677T) subjects always have significantly lower folate levels than heterozygous C677T. Subsequently, they also have remarkably higher homocysteine concentrations than everyone else; most pronounced when folate intake is low ( 9 ).