What diseases are caused by the Golgi apparatus?
Structural and functional changes of the Golgi apparatus are associated with several neurodegenerative diseases, such as Amyotrophic lateral sclerosis (28), Alzheimer’s disease (29), Parkinson’s disease (3), Huntington’s disease (30), Creutzfeldt-Jacob disease (31) and multiple system atrophy (32).
What happens if the Golgi apparatus is damaged?
Without a Golgi apparatus, there would be no lysosomes in a cell. Subsequently, the cell would not be able to digest or break down the materials left over from protein creation. This would create a lot of excess junk within the cell. If this happened, the cell wouldn’t be able to live for very long.
How does Parkinson’s disease affect the Golgi apparatus?
Fragmentation of the Golgi ribbon is a common feature of many neurodegenerative diseases but little is known about the causes of this alteration. In Parkinson’s disease, it is believed to be the consequence of an ER-Golgi transport imbalance and/or of cytoskeleton alterations.
How does Alzheimer’s affect the Golgi apparatus?
A recent study on Alzheimer’s disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from Aβ-induced fragmentation and reduces Aβ production.
What organelle causes the most diseases?
Malfunctioning mitochondria have been linked to diabetes, heart disease, Alzheimer’s disease, Parkinson’s disease and even normal aging.
What is the physiological result of dysfunction in the Golgi apparatus?
Disabling a part of brain cells that acts as a tap to regulate the flow of proteins has been shown to cause neurodegeneration, a new study has found.
What will happen if one organelle was removed?
Every organelle has a specific function which co-ordinate with other organelles to make the cell a functional & structural unit of life. So, if you take out an organelle, it will effect the functioning and ultimately the cell will be unfit to live.
What would happen if the rough ER stopped working?
The rough ER has attached ribosomes critical for protein synthesis. Smooth ER produce lipids and steroids etc so basically cells NEED these organelles. Without them many enzymatic processes would be unable to occur ultimately killing the cell.
What organelle is affected by Alzheimer’s disease?
The axonal transport and function of organelles like mitochondria and lysosomes may be impaired and play an important role in the pathogenesis of Alzheimer’s disease (AD).
What does smooth ER do?
smooth endoplasmic reticulum (SER), meshwork of fine disklike tubular membrane vesicles, part of a continuous membrane organelle within the cytoplasm of eukaryotic cells, that is involved in the synthesis and storage of lipids, including cholesterol and phospholipids, which are used in the production of new cellular …