What are the pathological changes in atherosclerosis?
The earliest pathologic descriptions of atherosclerotic lesions focused on morphologies of fatty streaks to fibroatheromas (FAs) and advanced plaques complicated by hemorrhage, calcification, ulceration, and thrombosis.
What are 5 risk factors for atherosclerosis?
What are the risk factors for atherosclerosis?
- High cholesterol and triglyceride levels.
- High blood pressure.
- Smoking.
- Type 1 diabetes.
- Obesity.
- Physical inactivity.
- High saturated fat diet.
What is atherosclerosis anatomy?
Atherosclerosis refers to a condition in which plaque gradually builds up in the wall of an artery. When fatty deposits containing cholesterol enter the blood vessel walls, immune cells are sent to the site to collect these fatty deposits, and transform them into hard plaque.
What is atherosclerosis give the etiology and pathogenesis of atherosclerosis?
Triglycerides, cholesterol and lipoproteins are implicated in the pathogenesis of coronary artery disease, especially atherosclerosis (9,10). Reduced concentrations of high density lipoprotein (HDL) and increased triglycerides have been shown to be responsible for the genesis of atherosclerotic lesions (17).
Is atherosclerosis a pathological condition?
atherosclerosis, chronic disease caused by the deposition of fats, cholesterol, calcium, and other substances in the innermost layer of endothelium of the large and medium-sized arteries.
What is atherosclerosis write its etiology and pathophysiology?
Atherosclerosis is the buildup of fats, cholesterol and other substances in and on your artery walls. This buildup is called plaque. The plaque can cause your arteries to narrow, blocking blood flow. The plaque can also burst, leading to a blood clot.
What age groups are most at risk of arteriosclerosis?
Genetic or lifestyle factors cause plaque to build up in your arteries as you age. By the time you’re middle-aged or older, enough plaque has built up to cause signs or symptoms. In men, the risk increases after age 45. In women, the risk increases after age 55.
What is the biochemical basis of atherosclerosis?
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the large arteries. The anatomy of a normal artery is shown in Fig. 1. The early lesions of atherosclerosis consist of subendothelial accumulations of cholesterol-engorged macrophages, called ‘foam cells’.
What is the major risk factor for developing atherosclerosis?
Major Risk Factors. Unhealthy blood cholesterol levels. This includes high LDL cholesterol (sometimes called “bad” cholesterol) and low HDL cholesterol (sometimes called “good” cholesterol). High blood pressure.