What are preferential COX-2 inhibitors?
The preferential COX-2 inhibitors noted in this article, namely meloxicam, nimesulide and etodolac (as well as nabumetone), are NSAIDs unavailable in Australia. Potential interactions with warfarin and lithium are noted with celecoxib but prescribers should also be cautious with rofecoxib.
Which is a selective COX-2 inhibitor?
Celebrex (celecoxib) is currently the only brand-name selective COX-2 inhibitor available in the United States; there are also generic versions of celecoxib.
Which of the following NSAIDs is a selective COX-2 inhibitor?
Two drugs that are claimed to be highly selective or specific in their ability to inhibit COX-2 while having little or no COX-1 affinity are rofecoxib and celecoxib. These selective NSAIDs reduce the pain and inflammation associated with rheumatoid arthritis and osteoarthritis.
What is the safest COX-2 inhibitor?
NEW ORLEANS, LA—Ten years in the making, with more than two out of three patients dropping out of the study, the PRECISION trial has found that the COX-2 inhibitor celecoxib is as safe—from a cardiovascular standpoint—as two of the world’s most popular anti-inflammatory drugs, ibuprofen and naproxen.
What are COX-2 selective NSAIDs?
COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Is etodolac a COX-2 inhibitor?
In summary, etodolac is a well established selective COX-2 inhibitor that has been shown not to suppress gastric or duodenal prostaglandins, to have minimal hepatic or renal effects and to have favourable GI tolerability in comparison with ibuprofen.
Is Ibuprofen a COX-1 or 2 inhibitor?
The main mechanism of action of ibuprofen is the non-selective, reversible inhibition of the cyclooxygenase enzymes COX-1 and COX-2 (coded for by PTGS1 and PTGS2, respectively).