How long is docetaxel effective?
Docetaxel extended predicted survival by an average of 0.89 years for patients with metastatic disease and 0.78 years for patients without metastatic disease. Docetaxel also extended discounted QALYs by 0.51 years for patients with metastatic disease and by 0.39 years for patients without metastatic disease.
Can docetaxel cure cancer?
Docetaxel and cabazitaxel have been shown to help men live longer, on average, than older chemo drugs. They may slow the cancer’s growth and also reduce symptoms, resulting in a better quality of life. Still, chemo is very unlikely to cure prostate cancer.
How effective is docetaxel?
Doses of 100 mg/m2 of docetaxel, administered over 1 hour every 3 weeks, produced an overall response rate of 50% (range, 41% to 58%) in 129 evaluable patients, with a median duration of 6 months (range, 2 to 17 months).
When should I start docetaxel?
Docetaxel is given after surgery to reduce the risk of breast cancer coming back in the future. It usually starts within a few weeks of your operation. If you are going to have radiotherapy you will usually complete your course of docetaxel first. When chemotherapy is given after surgery it is called adjuvant therapy.
Is docetaxel a strong chemo?
Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).
Does docetaxel shrink tumors?
Chemotherapy drugs, such as docetaxel, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors.
What cancer is docetaxel used for?
What Docetaxel Is Used For: Approved in treatment of breast cancer, non-small cell lung cancer, advanced stomach cancer, head and neck cancer and metastatic prostate cancer. Also being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers, soft tissue sarcoma and melanoma.
What does docetaxel do to cancer cells?
Docetaxel works by disrupting the microtubular network in cells, which is essential for cell division and other normal cellular functions. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die.
What If docetaxel does not work?
If docetaxel does not work or stops working, cabazitaxel (Jevtana) may be used.
Do you lose your hair with docetaxel?
You usually lose all the hair from your head. You may also lose your eyelashes and eyebrows, as well as other body hair.
How much does docetaxel cost?
The cost for docetaxel intravenous solution (20 mg/mL) is around $32 for a supply of 1 milliliter(s), depending on the pharmacy you visit….Intravenous Solution.
| Quantity | Per unit | Price |
|---|---|---|
| 1 milliliter | $31.94 – $34.45 | $31.94 – $34.45 |
| 4 milliliters | $22.27 – $22.97 | $89.06 – $91.89 |
How often do you infuse docetaxel in a day?
Patients who were randomly assigned to the docetaxel groups received either 75 mg of docetaxel (Taxotere, Aventis) per square meter as a 1-hour intravenous infusion on day 1 every 21 days or 30 mg of docetaxel per square meter as a 30-minute intravenous infusion on days 1, 8, 15, 22, and 29 of a 6-week cycle.
How are docetaxel and prednisone regimens chosen?
The docetaxel regimens were selected on the basis of their dose equivalence (a dose intensity of 25 mg per square meter of body-surface area per week and a maximal cumulative dose of 750 mg per square meter) and their activity and tolerability in phase 2 studies.
When to take dexamethasone before or after Docetaxel?
Premedication with dexamethasone was required in the docetaxel groups (8 mg given 12 hours, 3 hours, and 1 hour before the docetaxel infusion in the group treated every three weeks and 8 mg given 1 hour before docetaxel in the group treated weekly).