How is Palifermin administered?
The recommended dose of Kepivance is 60 mcg/kg/day, administered as an intravenous bolus injection for 3 consecutive days before and 3 consecutive days after myelotoxic therapy, for a total of 6 doses. Administer the first 3 doses prior to myelotoxic therapy.
What is Palifermin used for?
Palifermin is used to prevent and to speed the healing of severe sores in the mouth and throat that may be caused by chemotherapy and radiation therapy used to treat cancers of the blood or bone marrow (soft fatty material in the middle of bones that makes blood cells).
How much does Palifermin cost?
Results
| Outpatient per Diem Cost | Palifermin Mean Cost⁎ (95% CI) | Placebo Mean Cost⁎ (95% CI) |
|---|---|---|
| Hypothetical standard cost per patient | ||
| $500 | $80,967 ($76,807-$85,126) | $83,945 ($78,088-$89,803) |
| $1000 | $87,995 ($84,382-$91,608) | $90,345 ($85,114-$95,597) |
| $2000 | $102,051 ($99,674-$104,429) | $103,176 ($99,349-$107,004) |
What is mucositis?
Mucositis is when your mouth or gut is sore and inflamed. It’s a common side effect of chemotherapy and radiotherapy for cancer. Although mucositis is usually painful, it can be treated. It should get better within a few weeks of finishing cancer treatment.
How does amifostine work?
Amifostine is thought to work by preventing certain chemicals from damaging healthy cells. It may also help repair cells damaged by cisplatin or radiation treatment.
Is palifermin a chemotherapy?
Palifermin is used to decrease the chance of developing severe mucositis or to shorten the duration of severe mucositis in cancer patients receiving chemotherapy and radiation therapy, and undergoing autologous or allogeneic transplant. Palifermin is not a cancer treatment, but a supportive care medicine.
What is the best treatment for mucositis?
Management of bleeding In patients who are thrombocytopenic due to high-dose chemotherapy (eg hematopoietic cell transplant recipients), bleeding may occur from the ulcerations of oral mucositis.
How is Palifermin used in the treatment of cancer?
Use in Cancer. Palifermin is approved to prevent and treat: Oral mucositis that is severe. It is used in patients with leukemia or lymphoma who are being treated with high-dose chemotherapy and radiation therapy, followed by stem cell rescue. Palifermin is also being studied in the treatment of common side effects in other types of cancer.
Where does Palifermin come from in the body?
Palifermin is a recombinant keratinocyte growth factor (KGF) produced in E. coli. Endogenous KGF is produced by mesenchymal cells in response to epithelial tissue injury.
Are there any side effects to taking Palifermin?
Palifermin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: thick tongue. change in color of tongue. change in ability to taste food. increased or decreased feelings when touched, especially in and around the mouth. burning or tingling, especially in and around the mouth.
How is Palifermin used to treat mouth sores?
Palifermin is used to prevent and to speed the healing of severe sores in the mouth and throat that may be caused by chemotherapy and radiation therapy used to treat cancers of the blood or bone marrow (soft fatty material in the middle of bones that makes blood cells).