How do I know if my dog has MDR1?
There is a commercially-available test that assesses blood samples or a cheek swab for the presence of the MDR1 mutation. Ask your veterinarian about this test if your dog is a herding breed, or if you otherwise suspect the possibility of MDR1 mutation.
What percentage of Aussies have MDR1?
Breeds affected by the MDR1 mutation (frequency %)
| Breed | Approximate Frequency |
|---|---|
| Australian Shepherd | 50% |
| Australian Shepherd, Mini | 50% |
| Black Mouth Cur | Not enough tested to calculate |
| Border Collie | < 5% |
What genetic testing should be done for Australian shepherds?
What DNA tests should be mandatory? MDR1 for every Aussie. HSF4 cataract and CEA for breeding Aussies. Stud dogs offered at public stud should have all DNA health tests currently available for the breed.
What tests should Australian shepherds have?
For Aussies, the mandatory tests for certification are: hip & elbow OFA evaluation and eye evaluation. Optional testing includes autoimmune thyroiditis, Collie Eye Anomaly and Multiple Drug Sensitivity.
What is MDR1 in Aussies?
Multidrug Resistance 1, also called MDR1, is an inherited condition affecting several breeds of dogs, especially herding dogs such as the Australian shepherd. Thus, dogs that have one or two copies of the mutation are considered at-risk for adverse drug reactions.
How do you test for MDR1 in Australia?
A test for the MDR1 mutation is available through the laboratory that first discovered the mutation, the Veterinary Clinical Pharmacology Laboratory at Washington State University (vcpl.vetmed.wsu.edu). The test can be performed with a cheek swab test kit or EDTA whole blood.
What is MDR1 Aussie?
What medicines are Australian Shepherds allergic to?
Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and …
What is red factor in Australian shepherds?
A black dog, on the other hand, may produce puppies of either color if it happens to carry a liver version of the gene, referred to as ‘red factored”. Those with no liver version will never produce liver colored offspring.
Do all Aussies have MDR1?
Fortunately, there is an extremely accurate DNA test that will let you know whether your dog has this mutation. The mutation is so common in Australian Shepherds (roughly half have at least one copy) hat all of them, and even Aussie-mixes should be tested.
What heartworm medicine is best for Australian shepherds?
Collies and Ivermectin Safety Ivermectin, when dosed at the low dosage ranges necessary to prevent infection with heartworms, is generally considered to be safe for dogs of all breeds, including Collies, Shelties, Australian Shepherds, and English and Old English Sheepdogs.
Where can I test MDR1?