Can tamoxifen cause optic neuritis?
Pugesgaard and von Eyben13 reported the first case of optic neuritis in a patient on tamoxifen. The total dose was 6 g after 6 months on therapy, and the patient was left with severe optic atrophy in one eye despite discontinuation of the drug.
Can tamoxifen cause eye problems?
Extensive retinal lesions and macular edema with visual impairment have been reported in a few patients receiving high-dose tamoxifen. Less extensive retinal changes may occur in patients receiving low doses for long periods, and isolated retinal crystals may be observed in patients without visual symptoms.
What does tamoxifen do to the eyes?
The usual daily dose of tamoxifen is 20-40 mgs. Ocular side effects are relatively uncommon and are usually associated with higher doses. The ocular side effects are blurred vision, decreased visual acuity, vortex keratopathy, retinotoxicity, and bilateral optic neuritis.
What TB drug is most likely to cause optic neuritis?
Patients on linezolid-containing drug-resistant TB (DR-TB) regimen often develop adverse-events, particularly peripheral and optic neuropathy.
What is tamoxifen retinopathy?
Patients on tamoxifen can get striking white to yellow refractile bodies around the macula. These effects tend to occur at least one year after therapy begins and are cumulative.” But, according to Dr. Eisner, tamoxifen retinopathy is overemphasized.
What medications affect the optic nerve?
Causes of toxic optic neuropathy include chemicals and drugs, such as methanol, ethylene glycol, ethambutol, isoniazid, digitalis, cimetidine, vincristine, cyclosporine, toluene, and amiodarone.
What causes thickening of the optic nerve?
Papilledema occurs when increased pressure from the brain and cerebrospinal fluid is placed on the optic nerve. This causes the nerve to swell as it enters the eyeball at the optic disc.
Do tamoxifen side effects get worse over time?
“There is a subset of women who report this mental fog while on tamoxifen. Often, this improves over time. They initially experience this very noticeable side effect, but then it improves. We often tell women to try to stick it out because it may get better,” said Dr.
Is tamoxifen retinopathy reversible?
These complications seldom cause significant visual impairment and, except for crystalline retinopathy, are reversible upon discontinuation of tamoxifen.