Can loperamide cause liver damage?
Introduction. Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
What are the side effects of taking too much Imodium?
Symptoms of an overdose of Imodium can include:
- nausea.
- vomiting.
- severe drowsiness.
- pain in your abdomen.
- severe constipation.
Can loperamide cause problems?
Loperamide may increase your risk for stomach or bowel problems. Check with your doctor right away if you have bloating, blood in the stools, constipation, fever, loss of appetite, nausea or vomiting, or stomach pain.
Can Imodium cause toxic megacolon?
Medications that negatively impact bowel motility are also implicated in the development of toxic megacolon. These include, but are not limited to, anticholinergics, antidepressants, loperamide, atropine, and opioids.
Is Imodium an opioid derivative?
Imodium helps prevent and treat diarrhea by slowing down movement in your gut. Loperamide, the active ingredient in Imodium, is an opioid receptor agonist. That means it’s a type of opioid. It works by affecting proteins called opioid receptors found in cells in your gastrointestinal tract.
Is there opioids in Imodium?
Loperamide, the active ingredient in Imodium, is an opioid receptor agonist. That means it’s a type of opioid. It works by affecting proteins called opioid receptors found in cells in your gastrointestinal tract.
What happens if you take more than 4 Imodium in 24 hours?
Do not take more than the recommended amount. If you take 1 extra dose of loperamide as a one-off, it’s unlikely to harm you. But taking higher doses can cause serious heart problems. The signs include having a fast or irregular heartbeat.
What class of drug is loperamide?
Loperamide is in a class of medications called antidiarrheal agents. It works by decreasing the flow of fluids and electrolytes into the bowel and by slowing down the movement of the bowel to decrease the number of bowel movements.
What are the side effects of loperamide?
Dizziness, drowsiness, tiredness, or constipation may occur. If any of these effects persist or worsen, contact your doctor promptly.
Which is toxic megacolon associated with loperamide therapy?
Toxic Megacolon Associated With Loperamide Therapy. T OXIC megacolon is a well-known serious complication of fulminant ulcerative colitis and has been reported to occur in granulomatous colitis, typhoid fever, amebic colitis, malignant lymphoma, pseudomembranous enterocolitis, bacillary dysentery, and cholera.
Which is a complication of a toxic megacolon?
Toxic megacolon is a complication of these conditions: Ulcerative colitis. This is an inflammatory bowel disease. It usually affects the colon and rectum. Crohn’s disease. This is an inflammatory bowel disease. It can affect any part of the digestive tract. Infections of the colon. These can be caused by C difficile.
What are the side effects of loperamide therapy?
Rare (less than 0.1%): Bullous eruption (including Stevens-Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme), angioedema, urticaria, pruritus [ Ref] 1. Brown JW “Toxic megacolon associated with loperamide therapy.”
What causes toxic megacolon in people with IBD?
Causes. Toxic megacolon can be a spontaneous occurrence in people with particularly severe IBD. In some cases, it can result from the overuse of certain drugs, including narcotics; drugs used for pain relief, anticholinergics; drugs used for depression, anxiety and nervousness; and antidiarrheals, such as loperamide.