What are contraindications of artemether lumefantrine?
Who should not take COARTEM?
- low amount of magnesium in the blood.
- low amount of potassium in the blood.
- torsades de pointes, a type of abnormal heart rhythm.
- slow heartbeat.
- prolonged QT interval on EKG.
- abnormal EKG with QT changes from birth.
What is the contraindication of artemether?
CONTRAINDICATIONS / PRECAUTIONS Artemether; lumefantrine is metabolized primarily by CYP3A4 and is contraindicated with the concomitant use of strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, rifampin, St. John’s wort).
What is Artem used for?
The combination of artemether and lumefantrine is used to treat certain kinds of malaria infections (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death). Artemether and lumefantrine should not be used to prevent malaria.
What are the indication of Coartem?
Coartem Tablets are indicated for treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum in patients 2 months of age and older with a bodyweight of 5 kg and above.
Can I take paracetamol with artemether and lumefantrine?
No interactions were found between artemether / lumefantrine and Paracetamol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
How do I give Artem DS?
This medication is usually taken twice a day with a meal for 3 days (6 doses) or as directed by your doctor. On your first day of treatment, take your first dose with food, followed by your second dose 8 hours later. Then each day for the next 2 days, take one dose in the morning and one dose in the evening.
When are antimalarial medications contraindicated?
Contraindications. Amodiaquine should not be administered to patients with known hypersensitivity and should be avoided in patients with a history of hepatotoxicity, hepatic impairment, neutropenia or retinopathy.
Can artemether cause abortion?
Artemether / lumefantrine Pregnancy Warnings Risk summary: Published data from clinical trials and pharmacovigilance data have not associated use of this drug during pregnancy with major birth defects, miscarriage, or adverse maternal/fetal outcomes.
Can a breastfeeding mother take artemether lumefantrine?
Yes, mothers who are taking antimalarial medications may continue to breastfeed, provided they are healthy enough to do so. However, some medications used to treat malaria are not safe for breastfeeding infants who weigh less than 5 kg (11 lb), and should be avoided in breastfeeding mothers.
Does vitamin C affect malaria drugs?
Vitamin C may have additional detrimental effects in malaria. Results from an experimental study have shown that concurrent administration of artemether and ascorbic acid compromised the rates of parasite clearance in P.
Are there any side effects to taking artemether?
Talk to your doctor about using artemether/lumefantrine safely. This drug may make you feel dizzy or tired or weak. Alcohol or marijuana ( cannabis) can make you more dizzy or tired. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages.
Is it safe to take artemether with lumefantrine?
Coadministration of artemether-lumefantrine is contraindicated with strong CYP450 3A4 inducers (such as rifampin, carbamazepine, phenytoin, and St. John’s wort) where decreased levels of artemether and/or lumefantrine may lead to loss of antimalarial efficacy.
Is it safe to take dapsone with artemether?
Avoid coadministration of dapsone topical with oral dapsone or antimalarial medications because of the potential for hemolytic reactions. artemether/lumefantrine will decrease the level or effect of deflazacort by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
How does coadministration affect the level of artemether?
Coadministration can result in decreased concentrations and loss of antimalarial efficacy abametapir will increase the level or effect of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.