What is metronidazole IV used for?
Metronidazole injection is used to treat serious bacterial infections in different areas of the body. It is also used to prevent infections in the bowels before and after surgery for some patients. Metronidazole belongs to the class of medicines known as antibiotics.
Can metronidazole be given intravenously?
Metronidazole 500mg/100ml Intravenous Infusion should be infused intravenously at an approximate rate of 5 ml/minute (or one bag infused over 20 to 60 minutes). Oral medication should be substituted as soon as feasible.
Why metronidazole should be infused slowly?
Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation of metronidazole and its metabolites in the plasma. Accordingly, for such patients, doses below those usually recommended should be administered cautiously.
Is metronidazole a PO or IV?
Oral metronidazole has high bioavailability (98.9%) with peak plasma concentrations averaged at 2.3 h after dosing. Despite the high bioavailability of oral metronidazole, many patients continue to receive metronidazole intravenously when they are suitable for oral preparation.
What bacteria does metronidazole treat?
Metronidazole is highly active against gram-negative anaerobic bacteria, such as B. fragilis, and gram-positive anaerobic bacteria, such as C. difficile. The pharmacokinetic and pharmacodynamic properties of the drug are favorable, and it is available as oral, intravenous, vaginal, and topical formulations.
What is iv flagyl compatible with?
In a mixed aerobic and anaerobic infection, antibiotics appropriate for the treatment of the aerobic infection should be used in addition to FLAGYL I.V. FLAGYL I.V. is effective in Bacteroides fragilis infections resistant to clindamycin, chloramphenicol, and penicillin.
How do you inject metronidazole?
Metronidazole injection comes as a solution and is infused (injected slowly) intravenously (into a vein). It is usually infused over a period of 30 minutes to 1 hour every 6 hours. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to use metronidazole injection.
Why IV is given slowly?
Medications administered by direct IV route are given very slowly over AT LEAST 1 minute (Perry et al., 2014). Administering a medication intravenously eliminates the process of drug absorption and breakdown by directly depositing it into the blood.
Is metronidazole a painkiller?
Pain is the main complication. Multiple topical and systemic drugs have been investigated for pain control, but there is no ideal treatment. Metronidazole has been shown to decrease postoperative pain but is not used widely.
What are the indications of metronidazole?
metronidazole (Rx)
- Anaerobic Bacterial Infections. Loading dose: 15 mg/kg IV; not to exceed 4 g/day.
- Sexually Transmitted Disease. Prevention following sexual assault.
- Bacterial Vaginosis. Nonpregnant women.
- Colorectal Surgical Infection.
- Trichomoniasis.
- Amebiasis.
- Giardiasis (Off-label)
- Gardnerella Infection.
Is metronidazole a narcotic?
Narcotic abuse is found among people who take Metronidazole, especially for people who are female, 40-49 old , have been taking the drug for < 1 month, also take medication Seroquel, and have Pain.
What are the contraindications of metronidazole?
CONTRAINDICATIONS Hypersensitivity. FLAGYL Tablets is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives. Psychotic Reaction with Disulfiram. Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Interaction with Alcohol.
What is metronidazole oral tablet prescribed for?
Metronidazole immediate-release oral tablets mainly are recommended to treat various types of bacteria and parasites that cause infections in the human body. Most of these infections triggered by these bacteria and parasites attack the gastrointestinal tract and the reproductive system in females.
What is metronidazole and azithromycin used for?
Metronidazole is used to treat bacterial infections of the vagina, stomach or intestines, liver, skin, joints, brain, heart, and respiratory tract.