Does terbutaline cause birth defects?
Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders.
Is terbutaline safe in pregnancy?
Terbutaline injection should only be given to women who are in a hospital and should not be used to treat premature labor for longer than 48 to 72 hours. Terbutaline has caused serious side effects, including death, in pregnant women who took the medication for this purpose.
Why is terbutaline used during labor?
Terbutaline is a medication used to delay preterm labor. It is in a class of drugs called betamimetics, which help prevent and slow contractions of the uterus.
Does terbutaline cross placenta?
Terbutaline crossed the placenta rapidly, and fetal plasma levels up to 55% of the maternal plasma levels were found. The conclusion is that this form of administration of terbutaline does not seem to have any negative short-term influences on the fetal carbohydrate metabolism.
Can terbutaline cause fetal tachycardia?
Further, serious fetal adverse effects including fetal tachycardia, hyperinsulinemia, hyperglycemia, myocardial and septal hypertrophy and myocardial ischemia can also occur as result of terbutaline use in a pregnant woman (1-3).
What is indomethacin used for in pregnancy?
Indomethacin is often prescribed to pregnant women presenting with preterm labor or shortened cervix, which places them at risk for preterm labor and delivery. Indomethacin has been used since the 1970s to prolong pregnancy by decreasing uterine contractions.
Does terbutaline cause fetal tachycardia?
Increased fetal heart rate and neonatal hypoglycemia may occur as a result of maternal administration (1-3). Most common maternal adverse effects of terbutaline are headache, nausea, tachycardia and palpitations (1).
What are two 2 contraindications for the administration of terbutaline during labor?
Beta-mimetics (eg, terbutaline) may be contraindicated in the presence of cardiac arrhythmia, valvular disease, and ischemic heart disease and may alter glucose homeostasis in patients with diabetes.
How does terbutaline work in pregnancy?
Terbutaline is in a class of drugs called betamimetics. They help prevent and slow contractions of the uterus. It may help delay birth for several hours or days. During that period, doctors can administer other drugs to help ensure the baby is born as healthy as possible.
Can I take indomethacin while pregnant?
Women who are more than 32 weeks pregnant should avoid taking indomethacin, given the potential for heart problems in the baby. Women with a history of ulcers, bleeding disorders, or kidney or liver disease should also avoid taking indomethacin.
Is it safe to use terbutaline in pregnancy?
The extent of risks of using terbutaline during pregnancy isn’t known. A Category B pregnancy medication should only be given to a pregnant woman only in the case that the benefits to the patient outweigh the possible risks to the baby.
Why is Celestone given during pregnancy?
It is used to reduce inflammation, irritation, and pain. It is also used to treat skin problems, arthritis, and other joint or tendon problems. This medicine may also be given to pregnant women at risk for preterm delivery.
What is terbutaline used for?
The medicine Terbutaline is used to treat Asthma