Can IV hydromorphone be given orally?
Hydromorphone, a semisynthetic μ-opioid receptor agonist, is structurally similar to morphine. Hydromorphone can be administered orally (both IR and ER form), intravenously, or subcutaneously. IR hydromorphone has a short half-life of 2–3 h requiring administration every 4–6 h for pain management.
Where do you give hydromorphone?
Hydromorphone is injected under the skin or into a muscle, or as an infusion into a vein. A healthcare provider will give you this injection. Hydromorphone is usually given by injection only if you are unable to take the medicine by mouth or use another form of hydromorphone.
How do you administer liquid hydromorphone?
The usual adult oral dosage of DILAUDID ORAL LIQUID is one-half (2.5 mL) to two teaspoonfuls (10 mL) (2.5 mg – 10 mg) every 3 to 6 hours as directed by the clinical situation. Oral dosages higher than the usual dosages may be required in some patients.
How is hydromorphone administered in the human body?
Hydromorphone is administered by the oral, intravenous, intramuscular, and subcutaneous routes. Oral bioavailability is low (ranging from 25% to 50%), and protein binding is less than 20%. The kinetics are very similar to morphine.
How long does it take for hydromorphone to take effect?
Hydromorphone bioavailability ranges from 20% to 80% when administered by the oral route. Onset of analgesic effect occurs within 30 minutes when administered orally and 5 minutes when administered intravenously.
How often should I take a hydromorphone injection?
Adults—At first, 1 to 2 milligrams (mg) injected under the skin or into one of your muscles every 2 to 3 hours as needed. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.
How is hydromorphone used to treat opioid pain?
Hydromorphone oral liquid and tablets are used to relieve pain. The hydromorphone extended-release capsules and extended-release tablets are used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time.