What is CYP2D6 gene?
CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6) is a Protein Coding gene. Diseases associated with CYP2D6 include Drug Metabolism, Poor, Cyp2d6-Related and Neuroleptic Malignant Syndrome. Among its related pathways are Bupropion Pathway, Pharmacokinetics and Tamoxifen metabolism.
What does CYP2D6 code for?
CYP2D6 is responsible for codeine metabolism as well as the metabolism of about 25% fo all drugs.
What percent of drugs are metabolized by CYP2D6?
CYP2D6 is a major gene member of this superfamily as it carries out metabolism of 25% of drugs currently available in the market.
What does the CYP2D6 enzyme do in the body?
CYP2D6 is involved in the metabolism of many CNS drugs such as antidepressants, antipsychotics and opioids, as well as in the metabolism of endogenous neuroactive substrates (i.e. neuroactive monoamines, endocannabinoids and endomorphines).
What chromosome is CYP2D6 on?
The gene encoding the CYP2D6 enzyme is localized on chromosome 22 [18].
How is CYP2D6 inherited?
Cytochrome P450 CYP2D6 is the most extensively characterized polymorphic drug-metabolizing enzyme. A deficiency of the CYP2D6 enzyme is inherited as an autosomal recessive trait; these subjects (7% of Caucasians, about 1% of Orientals) are classified as poor metabolizers.
What is the genetic code for CYP2D6?
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra….
| CYP2D6 | ||
|---|---|---|
| showGene ontology | ||
| Orthologs | ||
| Species | Human | Mouse |
| Entrez | 1565 | n/a |
What is CYP2D6 substrate?
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. Hence, for drugs that are metabolized by CYP2D6 (that is, are CYP2D6 substrates), certain individuals will eliminate these drugs quickly (ultrarapid metabolizers) while others slowly (poor metabolizers).
What does the CYP2D6 * 10 allele do?
The CYP2D6*10 “C100T” mutation in patients leads to reduced enzyme activity and decrease of appropriate response to drug treatments, such as tamoxifen, codeine, antidepressants, and antipsychotics.