What is FH disease?
Familial hypercholesterolemia (FH) is a genetic disorder that affects about 1 in 250 people and increases the likelihood of having coronary heart disease at a younger age.
How do you diagnose FH?
FH is usually diagnosed clinically with a lipid test that measures the amount of LDL cholesterol (LDL-C) in the blood, a physical exam, and a family history. Healthcare providers typically use well-established criteria, to determine how likely it is that someone has FH.
What effect does FH have on the body?
Untreated, FH leads to early heart attacks and heart disease. *People with FH have a high amount of low density lipoprotein (LDL) or “bad cholesterol” due to a mutation in one of the genes that controls the way cholesterol is cleared by the body.
How is FH treated?
The most common treatment for FH is statin drug therapy. Statin drugs work by blocking an enzyme that produces cholesterol in the liver and increases your body’s ability to remove cholesterol from the blood. They can lower your LDL cholesterol levels by 50 percent or more.
Can FH disease be cured?
There isn’t a cure for FH but it can be treated. Treatment can reduce your risk of getting heart disease, having a heart attack or stroke, or needing other treatment. If you or your child is diagnosed with FH, speak with your doctor about the best treatment plan.
What is the treatment for FH?
What’s next for a person diagnosed with FH?
FH has no cure, but it’s treatable. Life expectancy with FH is lower without treatment, but the sooner you receive a correct diagnosis and start medication, the better your outlook and life expectancy. FH is inherited from one or both of your parents and requires treatment with medication to lower your LDL cholesterol.
Can FH be cured?
What treatments are available for FH?
What type of mutation causes FH?
FH is caused by a mutation in one of three genes: the low-density lipoprotein cholesterol receptor (LDLR), Apolipoprotein B gene (APOB), or a gain-of-function mutation in the gene for proprotein convertase subtilisin/kexin type-9 (PCSK9).
What does FH diabetes mean?
Importance Familial hypercholesterolemia is characterized by impaired uptake of cholesterol in peripheral tissues, including the liver and the pancreas. In contrast, statins increase the cellular cholesterol uptake and are associated with increased risk for type 2 diabetes mellitus.
How is familial hypercholesterolemia related to type 2 diabetes?
Importance Familial hypercholesterolemia is characterized by impaired uptake of cholesterol in peripheral tissues, including the liver and the pancreas. In contrast, statins increase the cellular cholesterol uptake and are associated with increased risk for type 2 diabetes mellitus.
What is the ICD 10 cm for diabetes mellitus?
Family history of diabetes mellitus. Z83.3 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
What causes high levels of LDL-C in FH?
FH is associated with extremely high levels of LDL-C due to mutations in the LDL receptor (LDLR) pathway, with mutations occurring mainly in APOB, LDLR, and PCSK9.