What does DNA protein kinase do?
The DNA-dependent protein kinase (DNA-PK) plays a critical role in DNA double-strand break (DSB) repair and in V(D)J recombination. DNA-PK also plays a very important role in triggering apoptosis in response to severe DNA damage or critically shortened telomeres.
What is DNA-PK inhibitor?
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.
What is Rad50?
phosphorylation of Rad50 plays a key regulatory role as an adaptor for specific ATM-dependent downstream signaling through SMC1 for DNA repair and cell cycle checkpoint control in the maintenance of genome integrity.
What is the function of RAD50 protein?
The protein complex including Mre11, Rad50, and Nbs1 (MRN) functions in DNA double-strand break repair to recognize and process DNA ends as well as signal for cell cycle arrest. Amino acid sequence similarity and overall architecture make Rad50 a member of the structural maintenance of chromosome (SMC) protein family.
What chromosome is RAD50 on?
| RAD50 | ||
|---|---|---|
| Location (UCSC) | Chr 5: 132.56 – 132.65 Mb | Chr 11: 53.65 – 53.71 Mb |
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| Wikidata | ||
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How is Dn-PKCS activated by DNA-activated protein kinase?
Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase. DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. DN-PKcs is activated under nutrient starvation and activates AktMST1, FoxO3a, and NDR1.
Which is the catalytic subunit of DNA-PK?
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
How does PRKDC interact with DNA-PKcs and Ku70?
Results show that under hypoxia, Ku70 and DNA-PKcs interact with nuclear RON which activates non-homologous end joining DNA repair conferring chemoresistance. A significantly different distribution was found in the frequency of PRKDC (rs7003908) genotype between the ESCC group and controls.
How does CDK2 and dna-pk2 regulate PR transcriptional activity?
CDK2 and DNA-PK regulate PR transcriptional activity by distinct mechanisms. Results show that under hypoxia, Ku70 and DNA-PKcs interact with nuclear RON which activates non-homologous end joining DNA repair conferring chemoresistance.