Which lipid lowering agents can worsen glycemic control?
Cumulative data suggest that both statins and niacin are associated with increased risk of impaired glucose control and development of new-onset diabetes, as opposed to bile-acid sequestrants which display concomitant moderate lipid and glucose lowering effects, and fibrates (particularly the pan-PPAR agonist …
Can Lipitor worsen glycemic control?
Background. Current evidence indicates that statins increase the risk of new onset diabetes mellitus (NOD) and also deteriorate the glycemic control in patients with known diabetes mellitus (DM) after high-dose statin therapy.
Does gemfibrozil worsen glycemic control?
Gemfibrozil treatment: 1) significantly reduces circulating triglyceride concentration; 2) does not significantly affect cholesterol concentration; 3) does not worsen glucose metabolism.
What do lipid lowering agents do?
Uses: These medications are used to lower cholesterol and triglyceride levels when diet and exercise alone have not lowered them enough. Reducing cholesterol and triglycerides helps prevent strokes and heart attacks. Each class of lipid-lowering agent can be used alone or in combination with another agent.
How do statins increase blood sugar?
Some studies have suggested that statins may cause hyperglycemia by increasing calcium concentration in the islet cells leading to decrease in insulin release or by decreasing GLUT 4-mediated peripheral glucose uptake.
Do all statins cause hyperglycemia?
Effect of high dose Atorvastatin (20 mg/kg/day) or Simvastatin (30 mg/kg/day) treatment for 30 days on different metabolic parameters in HSD induced pre-diabetic rats.
Is there a statin that doesn’t raise blood sugar?
The low-intensity statins—pravastatin, fluvastatin and lovastatin—had minimal effect on serum glucose.
What statin is best for diabetics?
Which is the best statin for people with diabetes?
- Atorvastatin (Lipitor)
- Fluvastatin (Lescol)
- Lovastatin (Mevacor)
- Pravastatin (Pravachol)
- Rosuvastatin (Crestor)
- Simvastatin (Zocor)
- Pitavastatin* (Livalo)
Can gemfibrozil lower blood sugar?
Gemfibrozil increases blood levels of repaglinide (Prandin) in people with diabetes, increasing the likelihood of developing low blood sugar (hypoglycemia). This combination should be avoided.
How do fibrates reduce hypertriglyceridemia in diabetic patients?
Fibric Acid Derivatives (Fibrates): Fibrates, namely gemfibrozil and fenofibrate, are the drugs of choice for hypertriglyceridemia. Fibrates activate PPARs, which lower TG levels by reducing TG synthesis in the liver through increased fatty-acid oxidation. This action decreases the TG content of VLDL particles.
What is a lipid lowering agent?
Statins are one of the better known types of cholesterol-lowering drugs. Statins decrease cholesterol output by blocking the HMG CoA reductase enzyme that the liver uses to make cholesterol.
What is an example of a lipid lowering drug?
Examples include Atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin.
How are lipid lowering drugs used in hyperlipidemia?
Although a change in life-style is often the method of first choice for lipid lowering, lipid-lowering drugs, in general, help to control elevated levels of different forms of lipids in patients with hyperlipidemia.
Are there any drugs that can lower LDL-C?
There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering cholesterol levels and they are the first line drugs for treating lipid disorders and can lower LDL-C levels by as much as 60%. Statins also are effective in reducing triglyceride levels in patients with hypertriglyceridemia.
How does lomitapide work to lower triglycerides?
Lomitapide inhibits microsomal triglyceride transfer protein decreasing the formation of chylomicrons in the intestine and VLDL in the liver. Both mipomersen and lomitapide have the potential to cause liver toxicity and therefore they were approved with a risk evaluation and mitigation strategy (REMS) to reduce risk.
Which is the best drug to lower triglycerides?
The ability of statins to lower triglyceride levels correlates with the reduction in LDL cholesterol [8]. Statins that are most efficacious in lowering LDL cholesterol are also most efficacious in lowering plasma triglyceride and VLDL cholesterol levels.