What is Avicel PH?
Avicel® PH is an ideal wet granulation binder which rapidly produces robust granules that remain stable in high shear environments, enabling broad processing windows and maximizing batch to batch reproducibility.
What is the difference between Avicel PH 101 and 102?
Avicel PH 101 is the original grade of MCC, while PH 102 is available as a partially agglomerated product with a larger particle size distribution and slightly better fluidity. Both grades show no significant difference in the compressibility [78].
What is the PH of microcrystalline cellulose?
Microcrystalline cellulose
| SYNONYMS | Cellulose gel, INS No. 460 |
|---|---|
| Loss on drying | Not more than 7.0% (105 °, 3h) |
| pH | 5.0 – 7.5 Shake 5 g of the sample with 40 ml of water for 20 min and centrifuge. Use the supernatant for pH determination |
| Water soluble substances | |
| Not more than 0.24% See description under TESTS |
What is avicel?
Avicel Trade name for microcrystalline cellulose that has been partially hydrolysed with acid, and reduced to a fine powder, used as a fat replacer. It disperses in water and has the properties of a gum.
Is avicel the same as microcrystalline cellulose?
Avicel PH, FMCs innovator brand of microcrystalline cellulose, is a purified, partially depolymerized alpha-cellulose made by acid hydrolysis of specialty wood pulp.
What is avicel filler?
Avicel, a microcrystalline cellulose powder, is another tolerable filler requested by prescribers and patients. Dyes are synthetic, chemical compounds that, when dissolved in a solvent, exhibit a coloring power or tinctoral strength. They are used in the production of many pharmaceutical products for many reasons.
Is microcrystalline cellulose the same as avicel?
Specialty Celluloses Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 °C for 15 min. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed.
What is avicel used for in tablets?
Avicel is used to extend starches, stabilize foams, and control ice crystal formation. Avicel has found widespread acceptance in the food industry for meringue, whipped toppings, confections, and ice cream, and is also used as a binder in pharmaceutical tablets and in cosmetics.
Is avicel soluble in water?
A water-soluble substance isolated from the leaves of seven plant species is shown to inhibit the fungal hydrolytic enzymes, pectinase and cellulase.
How is avicel produced?
Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 °C for 15 min. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed.
Is microcrystalline cellulose made from corn?
Most commercial microcrystalline cellulose powders are produced from dissolving pulp obtained from expensive hard woods using concentrated acids. α-Cellulose was extracted from an agricultural residue (corn cob) using a non-dissolving method.
Who makes avicel?
1. “Avicel® Cellulose Gel (Microcrystalline Cellulose) General Technology”, FMC Corp.
How big is a particle of Avicel ph-101?
The mean particle size is approximately 50 microns. What is the moisture content of Avicel® PH-101? The moisture content will vary in the range of 3 – 5%. What is the loose bulk density of Avicel® PH-101?
What kind of cellulose is Avicel PH-105?
Avicel PH-105 is a microcrystalline cellulose representing similar crystalline structure as the biomass samples have (α-cellulose) [1 ]. O -Acetyl-4- O -methyl- d -glucurono-xylan is a typical hardwood xylan, which was isolated from beech wood [ 8 ]. MWL was also isolated from beech wood according to the Björkman procedure [ 9 ].
How is Avicel PH200 considered as test bed material?
In the first case, Avicel PH200 is considered as test bed material. A PLS model is built between X and Y after Avicel PH200 data have been drawn from the databases. The model is then inverted to design the raw material properties xNEW in input to the granulation, to obtain a product of quality yDES.
Which is better grade 101 or 102 Avicel?
Both are deficient values due to the low MCC density. However, grade 101 has a higher “Compressibility” value (7.80) than grade 102 (6.63), as described above in the comparison of Avicel®, owing to a decrease in IC and Ie. Despite the “Compressibility” decrease, grade 102 only shows slightly higher “Flowability”.