What does PECAM mean?
Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.
What is CD31 marker for?
CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.
What does PECAM-1 bind to?
Heterophilic binding partners of PECAM-1 include the integrin αVβ3,70–72 CD38,73 and the neutrophil-specific CD17774; however, the physiological relevance of these interactions to platelets is currently not clear.
What does PECAM-1 do?
In addition to its role as an inhibitory receptor in circulating platelets and leukocytes, PECAM-1 is highly expressed at endothelial cell-cell junctions, where it functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability …
Is Pecam an integrin?
PECAM-1-Mediated Adaptive Stiffening Is an Integrin-Dependent Process.
What is CD31 and CD34?
CD34 is one of the Endothelial Cell Differentiation Markers and Endothelial Progenitor Cell Markers. CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils.
Where is CD31 located?
The platelet endothelial cell adhesion molecule-1 (PECAM-1), or CD31, a member of the immunoglobulin superfamily, is located on the plasma membrane of endothelial and hematopoietic cells and involved in vascular development and inflammation.
What is CD34 positive?
9.1 CD34. CD34 is a transmembrane glycoprotein expressed on early lymphohematopoietic stem cells, progenitor cells, and endothelial cells. Also, embryonic fibroblasts and some cells in fetal and adult nervous tissue are CD34-positive. The TdT+ subset of precursor B cells (hematogones) is also positive for CD34.
What are the GeneCards for the PECAM1 gene?
GeneCards Summary for PECAM1 Gene PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Capillary Hemangioma. Among its related pathways are Innate Immune System and Fluid shear stress and atherosclerosis.
How is PECAM-1 expressed in platelets and endothelial cells?
Patients who had optic neuritis that progressed to multiple sclerosis had a decrease in serum PECAM-1 levels. Platelet endothelial cell adhesion molecule (PECAM-1) is expressed in endothelial cells (ECs), platelets, and leukocytes, regulating the interaction between those cells.
What does the Entrez Gene do for EpCAM?
Entrez Gene Summary for EPCAM Gene This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule.
What kind of diseases are associated with EpCAM?
EPCAM (Epithelial Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with EPCAM include Diarrhea 5, With Tufting Enteropathy, Congenital and Colorectal Cancer, Hereditary Nonpolyposis, Type 8 . Among its related pathways are Cell surface interactions at the vascular wall and Adhesion .