What is an MTP INHIBITOR?
MTP is an endosomal protein present in hepatocytes and intestinal enterocytes. Microsomal triglyceride transfer protein Inhibitors (MTP-I) represent a new class of cholesterol and triglyceride lowering agents with the ability to affect the production of lipoproteins in both the liver and intestine. …
What is the basis of MTP inhibition as a hyperlipidemia drug?
Microsomal Triglyceride Transfer Protein Inhibitors It is thought that pharmacological inhibition of MTP results in hepatic production of VLDL, the precursor to LDL, causing a lowering of plasma LDL-C levels.
How do MTP inhibitors work?
The inhibition of microsomal triglyceride transfer protein (MTP) blocks the hepatic secretion of very low density lipoproteins (VLDL) and the intestinal secretion of chylomicrons.
What is the mechanism of action of mipomersen?
Mechanism of action Mipomersen binds to the messenger RNA coding for apolipoprotein B-100 (ApoB-100), a protein that is the main component of low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). As a consequence, the RNA is degraded by the enzyme ribonuclease H, and ApoB-100 is not translated.
What is MTP in biochemistry?
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles.
What do cholesterol absorption inhibitors do?
Cholesterol absorption inhibitors are used to treat high cholesterol in people who cannot take a statin. This medicine lowers total cholesterol and LDL (bad) cholesterol. This medicine is used along with lifestyle changes including diet and exercise to lower cholesterol.
What is a triglyceride fat?
What are triglycerides? Triglycerides are a type of fat (lipid) found in your blood. When you eat, your body converts any calories it doesn’t need to use right away into triglycerides. The triglycerides are stored in your fat cells. Later, hormones release triglycerides for energy between meals.
What is mipomersen used for?
Mipomersen injection is used to decrease levels of cholesterol and other fatty substances in the blood in people who have homozygous familial hypercholesterolemia (HoFH; a rare inherited condition that causes very high levels of cholesterol in the blood, increasing the risk of serious heart disease).