What does a positive anti histone antibodies mean?
Results of histone antibody testing consider several factors. A positive result means that a person likely has drug-induced lupus if the person also has: Symptoms associated with lupus. Been taking a drug, especially one associated with the condition, for several weeks to a couple of years.
What is an antihistone test?
Description. Order an antihistone antibodies blood test to help in the diagnosis and monitoring of drug-induced lupus erythematosus. Histone antibodies are autoantibodies that are produced by a person’s immune system from their histones.
What is the normal range for histone antibody?
Reference Range(s)
| Value | Explanation of Results |
|---|---|
| <1.0 | Negative |
| 1.0-1.5 | Weak Positive |
| 1.6-2.5 | Moderate Positive |
| >2.5 | Strong Positive |
Which tests would be positive for histones?
A value of greater than 1.5 units relative to a control serum is considered a positive ELISA test for the anti-histone antibodies. Patients with Drug-Induced Lupus Erythematosus typically have positive tests for anti-histone antibodies but do not have indications for Anti-dsDNA antibodies.
What does 2, 4-dinitrophenol do to your body?
2,4-Dinitrophenol elevates the BMR, lowers the serum T4 concentration, accelerates the peripheral metabolism of T4, and depresses thyroidal RAIU and secretion. 391,392 Its actions are probably complex. Like T4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria.
What is the detection limit for 2, 4-dinitrophenol?
Under the prescribed conditions, for 2,4-dinitrophenol the method detection limit is 13.0 ug/l using flame ionization detection and 36.0 ug/l using electron capture detection. Precision and method accuracy were found to be directly related to analyte concentration and essentially independent of the sample matrix.
What is the pKa of 2, 4-dinitrophenol?
The pKa of 2,4-dinitrophenol is 4.09 (4), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts (5). This can be seen in the measured Koc values (SRC).
When was 2, 4-dinitrophenol first used for weight loss?
2-4-Dinitrophenol (DNP) was one of the first antiobesity therapy used in the 1930s.11 Its effect was first noticed among factory workers who were exposed to this and lost weight.