What causes sensory ganglionopathy?
The most common cause of sensory neuronopathy is thought to be immune-mediated damage to the DRG neurons. This often affects both the central and peripheral “T-shaped” neurons and their projections, rather than specific sections that are evident and many other polyneuropathies.
What is sensory polyneuropathy?
Sensory polyneuropathies, which are caused by dysfunction of peripheral sensory nerve fibers, are a heterogeneous group of disorders that range from the common diabetic neuropathy to the rare sensory neuronopathies.
What is autoimmune sensory Ganglionopathy?
Autoimmune autonomic ganglionopathy refers to a pure autonomic neuropathy, which typically affects both cholinergic and adrenergic functions. About a half of the patients with autoimmune autonomic ganglionopathy are positive for anti-ganglionic acetylcholine receptor antibodies.
What is happening to the nerves in neuropathy?
The tracks (the network of nerves) allow the trains (information signals) to travel to and from the central station (your brain and spinal cord). Neuropathy results when nerve cells, called neurons, are damaged or destroyed. This disrupts the way the neurons communicate with each other and with the brain.
Is polyneuropathy an autoimmune disease?
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction.
Are there any disorders of the dorsal root ganglion?
This includes paraneoplastic and immune-mediated nonmalignant inflammatory sensory polyganglionopathies as well as sensory ganglionopathy associated with Sjögren syndrome and toxic and nutritional ganglionopathies. Dive into the research topics of ‘Dorsal root ganglion disorders’.
What are the symptoms of sensory ganglionopathy?
These may include lack of voluntary muscle movement coordination and abnormal gait. Other symptoms may include: Areflexia. Pseudoathetotic hand movements. Allodynia. Tonic pupils. Orthostatic hypotension. Gastrointestinal effects.
What are the symptoms of autonomic ganglionopathy ( AAG )?
Symptoms may include severe orthostatic hypotension (low blood pressure upon standing), fainting, constipation, fixed and dilated pupils, urinary retention, and dry mouth and eyes. The underlying cause of AAG is poorly understood.