What does Robertsonian translocation do?
A Robertsonian translocation results when the long arms of two acrocentric chromosomes fuse at the centromere and the two short arms are lost. If, for example, the long arms of chromosomes 13 and 14 fuse, no significant genetic material is lost—and the person is completely normal in spite of the translocation.
Is there a cure for Robertsonian translocation?
In most cases, Robertsonian translocation does not cause any health problems or require treatment. People who carry the abnormality, however, may pass it on to their children. Aspiring parents may wish to seek genetic counseling before starting a family.
Can Robertsonian translocation cause Down’s syndrome?
Downs syndrome (DS) occurs due to an extra copy of chromosome 21. About 3% of cases of Downs syndrome occur due to Robertsonian translocation, most commonly t (14; 21), other types of translocations are very rare cause of the syndrome.
Is Robertsonian translocation a trisomy?
A trisomy is a genetic alteration in which there is an extra copy of a chromosome in a DNA strand, throwing the chain off balance. A Robertsonian translocation can result in trisomy 14 or trisomy 21. Trisomy 21 is also known as Down syndrome.
What are the symptoms of Robertsonian translocation?
In most cases , there are no symptoms or visible signs of a Robertsonian translocation. Depending on where in your DNA the translocation occurs, it’s very likely that you won’t experience any side effects of your DNA chain being atypical.
Are Robertsonian translocations balanced?
Robertsonian Translocations Genetically balanced carriers of these translocations have an increased incidence of infertility as well as a risk for genetic imbalances among their offspring.
Can Edwards syndrome be detected before birth?
Edwards’ syndrome can be detected before birth. If a pregnant woman is older than 35, has a family history of genetic abnormalities, has previously conceived a child with a genetic abnormality, or has suffered earlier miscarriages, she may undergo tests to determine whether her child carries genetic abnormalities.
Which is the most Common Robertsonian translocation in humans?
The acrocentric chromosomes in this DNA chain are chromosomes 13, 14, 15, 21, and 22. Common translocation formations include: chromosome 13 with chromosome 14 (the most common Robertsonian translocation and the most common chromosome rearrangement found in humans) chromosome 13 with chromosome 21. chromosome 14 with chromosome 21.
Can a person with Robertsonian translocation have Down syndrome?
Trisomy 21 is also known as Down syndrome. Down syndrome is the world’s most common genetic disorder. If your Robertsonian translocation fuses another chromosome with chromosome 21, you may be genetically more predisposed to have a baby with Down syndrome.
How is Patau syndrome related to Robertsonian translocation?
Patau syndrome is a result of an extra copy of chromosome 13 in a developing fetus’s DNA. If your Robertsonian translocation fuses chromosome 13 with another chromosome, you may be a carrier for Patau syndrome. Most cases of this trisomy aren’t inherited, but it’s possible.
Are there any side effects of a Robertsonian translocation?
In most cases, there are no symptoms or visible signs of a Robertsonian translocation. Depending on where in your DNA the translocation occurs, it’s very likely that you won’t experience any side effects of your DNA chain being atypical.