What is Cmax and CMIN?
The peak concentration that a drug achieves in a specified compartment after the drug has been administrated and before administration of a second dose. Cmax is the opposite of Cmin—which is the minimum (or trough) concentration that a drug achieves after dosing.
What is PK curve?
The creation of a pharmacokinetic (PK) curve, which follows the plasma concentration of an administered drug as a function of time, is a critical aspect of the drug development process and includes such information as the drug’s bioavailability, clearance, and elimination half-life.
What are the 4 pharmacokinetic principles?
There are four main components of pharmacokinetics: liberation, absorption, distribution, metabolism and excretion (LADME). These are used to explain the various characteristics of different drugs in the body.
What is RAC in pharmacokinetics?
Rac(AUC) – Accumulation ratio calculated from AUCτ,ss and AUCτ after single dosing.
What is Cmax pharmacokinetics?
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. It is a standard measurement in pharmacokinetics.
What is Cmax in pharmacokinetics?
Peak Concentration. A pharmacokinetic measure used to determine drug dosing. Cmax is the highest concentration of a drug in the blood, cerebrospinal fluid, or target organ after a dose is given.
What is peak plasma level?
Cmax is the highest inhibitor concentration reached in the blood in vivo and is an approximation of the inhibitor concentration (I) at the enzymes in the liver. From: Drug-Like Properties (Second Edition), 2016.
What are the 5 principles of pharmacokinetics?
Definition of Pharmacokinetics They are absorption, distribution, metabolism, and excretion. Each of these processes is influenced by the route of administration and the functioning of body organs. Let’s look at these processes in further detail.
What are the 5 steps of pharmacokinetics?
Pharmacokinetics is the movement of a drug through the body’s biological systems, these processes include absorption, distribution, bioavailability, metabolism, and elimination.
What is VD pharmacokinetics?
The volume of distribution (Vd) is a pharmacokinetic parameter representing an individual drug’s propensity to either remain in the plasma or redistribute to other tissue compartments.