How do BRAF inhibitors work?
The BRAF inhibitors vemurafenib, dabrafenib and encorafenib are used in the treatment of patients with BRAF-mutant melanoma. They selectively target BRAF kinase and thus interfere with the mitogen-activated protein kinase (MAPK) signalling pathway that regulates the proliferation and survival of melanoma cells.
Is sorafenib a BRAF inhibitor?
In the laboratory setting, sorafenib is able to block V600EBRAF and downstream activation of the MAP kinase pathway. However, the concentrations of the drug needed to induce cell death also kill melanoma cells that lack a BRAF mutation.
What is Tafinlar and Mekinist used for?
TAFINLAR and MEKINIST are prescription medicines that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene.
What does MEK inhibitor do?
MEK inhibitors bind to and inhibit MEK, inhibiting MEK-dependent cell signaling. This inhibition leads to cell death and the inhibition of tumor growth. These are allosteric binding inhibitors of MEK which inhibit either MEK1 alone, or both MEK1 and MEK2.
Is trametinib a chemotherapy drug?
Trametinib is the generic name for the trade name chemotherapy drug Mekinist. In some cases, health care professionals may use the trade name Mekinist when referring to the generic name trametinib. Drug type: Trametinib is a targeted therapy.
Is sorafenib an immunotherapy?
The overall results suggest that immunotherapy consisting of the combination of sorafenib/anti-PD-L1 mAb could be a promising new approach for treating patients with HCC.
Is sorafenib considered chemotherapy?
Nexavar (sorafenib) is a cancer (chemotherapeutic) medication used to treat a type of kidney cancer called advanced renal cell carcinoma. Nexavar is also used to treat liver cancer.