Is zileuton a lipoxygenase inhibitor?
Background and purpose: Zileuton is the only 5-lipoxygenase (5-LOX) inhibitor marketed as a treatment for asthma, and is often utilized as a selective tool to evaluate the role of 5-LOX and leukotrienes.
Which agent is a 5-lipoxygenase inhibitor?
The overproduction of leukotrienes is a major cause of inflammation in asthma, allergic rhinitis, and osteoarthritis. Examples of 5-LOX inhibitors include the pharmaceutical drugs meclofenamate sodium, zileuton and the natural products myxochelins/pseudochelin as well as nordihydroguaiaretic acid (NDGA).
What drug blocks lipoxygenase?
Lipoxygenase Inhibitors
| Drug | Target | Type |
|---|---|---|
| Diethylcarbamazine | Arachidonate 5-lipoxygenase | target |
| Diethylcarbamazine | Prostaglandin G/H synthase 1 | target |
| Diethylcarbamazine | Cholinesterase | enzyme |
| Licofelone | Arachidonate 5-lipoxygenase | target |
What effect does a lipoxygenase inhibitor have?
Lipoxygenase inhibitors can reversibly block NK and NC activity, and this inhibition can be effectively reversed by LTB4, indicating that exogenous lipoxygenase products can compensate for endogenous lipoxygenase inhibition.
What kind of drug is zileuton?
Zileuton belongs to a class of medications called leukotriene synthesis inhibitors. It works by stopping the formation of certain natural substances that cause swelling, tightening, and mucus production in the airways.
What is the adverse effect of zileuton?
Zileuton side effects nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); skin rash, bruising, severe tingling, numbness, pain, muscle weakness; mood or behavior changes, anxiety, depression, or thoughts about suicide or hurting yourself; or.
What does 5-lipoxygenase do?
5-Lipoxygenase (ALOX5) is an iron-containing and nonheme dioxygenase that catalyzes the peroxidation of polyunsaturated fatty acids such as arachidonic acid. ALOX5 is the rate-limiting enzyme for the biosynthesis of leukotrienes, a family of proinflammatory lipid mediators derived from arachidonic acid.
Do 5-LOX inhibitors work?
The balanced inhibitors of 5-lipoxygenase (5-LOX) and of cyclooxygenase (both types 1 and 2) block the formation of all the enzymatically arachidonic acid-derived metabolites, both prostaglandins (like COX inhibitors) and leukotrienes (LT); these drugs have been shown to possess a very good anti-inflammatory efficacy …
Which of the following drugs is a 5-lipoxygenase 5 log inhibitor?
Zileuton is the only 5-lipoxygenase (5-LOX) inhibitor marketed as a treatment for asthma, and is often utilized as a selective tool to evaluate the role of 5-LOX and leukotrienes.
What does 5-LOX inhibitor do?
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
Is zileuton a controlled substance?
Zileuton is used in the treatment of asthma, maintenance and belongs to the drug class leukotriene modifiers. Risk cannot be ruled out during pregnancy. Zileuton 600 mg is not a controlled substance under the Controlled Substances Act (CSA).
What is zileuton good for?
Zileuton is used to prevent wheezing, shortness of breath, coughing, and chest tightness due to asthma. Zileuton is not used to treat an asthma attack (sudden episode of shortness of breath, wheezing, and coughing) that has already started.