What causes paroxysmal extreme pain disorder?
Paroxysmal extreme pain disorder is caused by mutations in the SCN9A gene . This condition is inherited in an autosomal dominant pattern. Treatment may include medications used to manage chronic neuropathic pain (anticonvulsants) such as the sodium channel blocker carbamazepine.
How common is PEPD?
PEPD is an extremely rare disorder with only 15 known affected families.
What is a pain disorder?
A pain disorder is chronic pain experienced by a patient in one or more areas. The pain is often so severe that it disables the patient from normal functioning. The duration may be as short as a few days or as long as many years.
How rare is paroxysmal extreme pain?
Paroxysmal extreme pain disorder is a rare condition; approximately 80 affected individuals have been described in the scientific literature.
What is paroxysmal pain syndrome?
Paroxysmal extreme pain disorder is a condition characterized by skin redness and warmth (flushing) and attacks of severe pain in various parts of the body. The area of flushing typically corresponds to the site of the pain.
Is Fibromyalgia a pain disorder?
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Researchers believe that fibromyalgia amplifies painful sensations by affecting the way your brain and spinal cord process painful and nonpainful signals.
What conditions are considered chronic pain?
Chronic pain is pain that is ongoing and usually lasts longer than six months. This type of pain can continue even after the injury or illness that caused it has healed or gone away….Chronic pain is linked to conditions that include:
- Headache.
- Arthritis.
- Cancer.
- Nerve pain.
- Back pain.
- Fibromyalgia.
What is Dysesthesia pain?
Abstract. Dysesthesia is a generic term for a cutaneous symptom–such as pruritus, burning, tingling, stinging, anesthesia, hypoesthesia, tickling, crawling, cold sensation, or even pain–without a primary cutaneous condition in a well-defined location that is often caused by nerve trauma, impingement, or irritation.
What is the disease where you don’t feel pain?
Congenital insensitivity to pain and anhydrosis (CIPA) is a rare hereditary disease that causes affected individuals to be unable to feel pain and unable to sweat (anhydrosis). It is also called hereditary sensory and autonomic neuropathy type IV (HSAN IV).