What is an FP receptor?
The prostaglandin F2α receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues. 1. FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney.
What is the precursor to PGF2a?
acid, the immediate precursor of PGE2 and PGF2a, directly into the corpus luteum (49). Arachidonic acid previously had been isolated from bovine endometrium and was luteolytic in the psudopregnant hysterectomized hamster (17).
Where is prostaglandin f2a produced?
uterus
In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the luteal phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone.
What structure does prostaglandin f2alpha travel through in order to leave the uterus?
During luteolysis, PGF(2alpha) is synthesized and released from the endometrium in a pulsatile pattern. The unique structure of the vascular utero-ovarian plexus (UOP) allows transport of luteolytic PGF(2alpha) pulses directly from the uterus to the ovary, thus bypassing the systemic circulation.
Is a chemical that binds to a receptor and activates the receptor to produce a biological response?
agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
Does PGE2 cause vasodilation?
In the kidney, arachidonic acid, PGE2, D2, and I2 all produce vasodilation when studied by bolus injection techniques. PGF2 alpha is relatively inactive. In the mesenteric vascular bed arachidonate, PGE2 and PGI2 are vasodilators whereas PGD2 and PGF2 are vasoconstrictors.
How do prostaglandins cause vasodilation?
Most prostaglandins act locally; for instance, they are powerful locally acting vasodilators. Vasodilation occurs when the muscles in the walls of blood vessels relax so that the vessels dilate. This creates less resistance to blood flow and allows blood flow to increase and blood pressure to decrease.
How does prostaglandin F2α bind to PGF 2α?
The PGF 2α isoform 8-iso-PGF2α was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress. PGF 2α acts by binding to the prostaglandin F2α receptor.
What is the role of the prostaglandin F receptor?
Prostaglandin F receptor ( FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of Prostaglandin F2α (PGF 2α ). It is encoded in humans by the PTGFR gene.
Why is PGF 2α released in the uterus?
It is released in response to an increase in oxytocin levels in the uterus, and stimulates both luteolytic activity and the release of oxytocin. Because PGF 2α is linked with an increase in uterine oxytocin levels, there is evidence that PGF 2α and oxytocin form a positive feedback loop to facilitate the degradation of the corpus luteum.
What happens when PGF 2α is injected into the body?
When injected into the body or amniotic sac, PGF 2α can either induce labor or cause an abortion depending on the concentration used. In small doses (1–4 mg/day), PGF 2α acts to stimulate uterine muscle contractions, which aids in the birth process.