When is heparin used for DVT prophylaxis?
Patients with a first episode of proximal DVT and no risk factors for bleeding complications (e.g., active peptic ulcer disease, thrombocytopenia, liver disease, other coagulopathy) are good candidates for initial therapy with low-molecular-weight heparin.
What is heparin dosing?
Unstable Angina/NSTEMI Initial IV bolus of 60-70 units/kg (max: 5000 units), THEN initial IV infusion of 12-15 units/kg/hr (max: 1000 units/hr) Dose should be adjusted to maintain aPTT of 50-70 sec.
How do you give heparin for DVT?
A protocol for IV heparin use is as follows:
- Give an initial bolus of 80 U/kg.
- Initiate a constant maintenance infusion of 18 U/kg.
- Check the aPTT or heparin activity level 6 hours after the bolus, and adjust the infusion rate accordingly.
What is the therapeutic range for heparin?
The therapeutic range for unfractionated heparin with this assay is 0.3 to 0.7 U/mL.
What is the recommended route of administration for heparin?
As the effects of heparin are short-lived, administration by intravenous infusion or subcutaneous injection is preferable to intermittent intravenous injections. followed by: 5,000 units subcutaneously every 8-12 hours, for 7-10 days or until the patient is fully ambulant.
What is the difference between UFH and LMWH?
Compared with UFH, the LMWH enoxaparin binds less avidly to plasma proteins, and therefore has increased bioavailability and duration of action. When coupled with antithrombin III, enoxaparin has weaker activity against thrombin, but unlike UFH, it has more potent inhibition of factor Xa.
How do you calculate heparin?
- Heparin Infusion Rate: 25,000 units = 1500 units/hour.
- 500ml.
- X (ml/hour)
- 25,000 units (X ml/hr) = 750,000.
- X ml/hr = 750,000.
- 25,000.
- X = 30 ml/hour.