What does high TIBC mean in a blood test?
A high TIBC, UIBC, or transferrin usually indicates iron deficiency, but they are also increased in pregnancy and with the use of oral contraceptives. A low TIBC, UIBC, or transferrin may also occur if someone has malnutrition, inflammation, liver disease, or nephrotic syndrome.
What is TIBC normal range?
Normal Results Normal value range is: Iron: 60 to 170 micrograms per deciliter (mcg/dL) or 10.74 to 30.43 micromoles per liter (micromol/L) TIBC: 240 to 450 mcg/dL or 42.96 to 80.55 micromol/L. Transferrin saturation: 20% to 50%
Should TIBC be high or low?
Normal values for the TIBC test can vary among laboratories. However, most laboratories define a normal range for adults as 250 to 450 micrograms per deciliter (mcg/dL). A TIBC value above 450 mcg/dL usually means that there’s a low level of iron in your blood.
What should your TIBC be?
Normal results for TIBC are 250 to 450 mcg/dL for men and women. Some common causes for a low amount of iron in your blood include: Iron deficiency anemia. Other types of anemia.
How do you read TIBC?
If you have iron deficiency (a lack of iron in your blood), your iron level will be low but your TIBC will be high. If you have too much iron (for example, if you have a condition like haemochromatosis), your iron level will be high but your TIBC will be low or normal. Transferrin is a protein produced by the liver.
Why is TIBC high in iron deficiency?
In iron-deficient conditions, the relative transferrin content compared to iron content increases, and thus the TIBC values are high. The opposite happens in iron overloaded states of the body; the quantity of free transferrin in blood decreases, and consequently, TIBC values are low.
What causes low TIBC?
The most common cause of low TIBC is excess iron in the body [7]. Iron overload can happen due to poisoning, or in some hereditary disorders, such as hemochromatosis, thalassemia, or sickle cell anemia [7, 8]. However, not everyone with iron overload will have low TIBC.
Is TIBC the same as ferritin?
total iron binding capacity (TIBC) – measures the transferrin capacity to bind iron; serum ferritin – measures the body’s ability to store iron.
Why is TIBC low in anemia of chronic disease?
The total iron-binding capacity (TIBC), an indirect measurement of transferrin, is low in anemia of chronic disease because there is ample iron, but it is not easily available. TIBC tends to be increased when iron stores are diminished and decreased when they are elevated.