What is the function of pathogen recognition receptors?
Pathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity is developed.
What is the function of PRRs?
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns—DAMPs).
Where are pathogen recognition receptors?
There are present at the cell surface to recognise extracellular pathogens such as bacteria or fungi, in the endosomes where they sense intracellular invaders such as viruses and finally in the cytoplasm. These receptors recognise conserved molecular structures of pathogens.
What is the role of pathogen recognition receptors?
Pathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity is developed.
How are pattern recognition receptors related to PAMPs?
The so-called Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently associated with pathogens (aka Pathogen-Associated Molecular Patterns—PAMPs). A more comprehensive description of PRRs and their signaling transduction pathways can be found elsewhere (3).
How are pathogen-associated molecular patterns recognized in cells?
Cells of the host recognize structures called pathogen-associated molecular patterns (PAMPs) via germ line-encoded pattern recognition receptors (PRRs) present in their extracellular milieu and endosomal compartments [ 2
How does the immune system recognize a pathogen?
The innate immune response relies on recognition of evolutionarily conserved structures on pathogens, termed pathogen-associated molecular patterns (PAMPs), through a limited number of germ line-encoded pattern recognition receptors (PRRs), of which the family of Toll-like receptors (TLRs) has been studied most extensively (7, 242).